Hepple, RussellAshmead, Jon C.2005-08-162005-08-162004Ashmead, J. C. (2004). Role of arterial PO2 and PCO2 in the regulation of brachial blood flow in humans (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/208230612976270http://hdl.handle.net/1880/41672Bibliography: p. 128-152Some pages are in colour.This study examined the role of arterial PO2 (PaO2) and PCO2 (PaCO2) in the regulation of brachial blood flow (BBF) in humans. Nine healthy male subjects participated in five 60-min experimental conditions: isocapnic hypoxia, isocapnic hyperoxia, euoxic hypocapnia, euoxic hypercapnia, and euoxia isocapnia (control). Dynamic end-tidal forcing was used to control end-tidal (i.e., arterial) PO2 and PCO2. Doppler ultrasound was used to measure BBF. Hypoxia elicited a sustained increase in BBF (25 ± 14%; P<0.05), whereas hyperoxia caused a sustained decrease in BBF (15 ± 8%; PO.05). Hypocapnia elicited a biphasic response, where BBF transiently increased (31 ± 17%; PO.05) after 2 min and abruptly declined (25 ± 14% below baseline) thereafter. During hypercapnia BBF initially increased (14 ± 10%; P<0.05), but returned to baseline values after 20 min. The present study provides direct evidence that alterations in PaO2 and PaCO2 have dynamic effects on blood flow regulation through the brachial artery. brachial blood flow, hypoxia, hyperoxia, hypocapnia, hypercapnia, euoxia, isocapniaxvii, 202 leaves : ill. ; 30 cm.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.master thesis10.11575/PRISM/20823AC1 .T484 2004 A77