Schryvers, AnthonyJacob, ChristianKellner, JimAdamiak, Paul2013-05-012013-06-102013-05-012013Adamiak, P. (2013). Patterns of sequence and structural variation within the Neisseria meningitidis transferrin and lactoferrin receptor systems (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27277http://hdl.handle.net/11023/693Invasive meningococcal disease resulting from infection by Neisseria meningitidis is the source of a substantial burden of bacterimia and meningitis in both the developed and developing worlds. Within the human host, N. meningitdis encounters a hostile environment deficient in freely available iron. In order to survive, N. meningitidis has evolved two receptor systems that sequester iron from the host iron transport glycoproteins transferrin and lactoferrin. Both the meningococcal transferrin and lactoferrin receptor systems consist of an outer membrane embedded A protein and a membrane anchored B lipoprotein. Both proteins of these systems are highly immunogenic and functionally important. The opposing selective forces of host immunity and functional necessity have resulted in complex patterns of sequence variation in the genes for these receptors. The research discussed here investigates these patterns with a focus on understanding the functional and structural factors that constrain variability.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.MicrobiologyBiology--MolecularImmunologyNeisseriatransferrinLactoferrinBioinformaticsmaster thesis10.11575/PRISM/27277