Krawetz, RomanAl-Jezani, Nedaa2016-12-072016-12-0720162016Al-Jezani, N. (2016). Cell Surface Receptors Expression Profile Of Human Synovial Mesenchymal Stem Cells In-Situ And In-Vitro From Normal And Osteoarthritic Knee Joints (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25235http://hdl.handle.net/11023/3479Osteoarthritis is a chronic disease that results in the degeneration of the articular cartilage, eventually affecting the whole joint. Due to the lack of regenerative capacity in the articular cartilage, synovial mesenchymal stem cells, having chondrogenic capacity and derived from the synovium (SMSCs) are an attractive source for articular cartilage regeneration. However, it is important to identify the optimal SMSCs that have tri-lineage potential, which will help the regeneration of the whole joint. Unfortunately, MSC populations are phenotypically heterogeneous, in terms of their cell surface expression. In this project, SMSCs derived from OA joint with the optimal differentiation capacity display a marker profile of CD90+, CD44+, and CD73+. However, the same profile was expressed on clones that didn’t present with multi-potential differentiation capacity. Therefore, additional markers are necessary to accurately purify SMSCs that would may have increased regenerative capacity for use in cell therapies for patients with OA.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Human DevelopmentMedicine and SurgeryStem cells, osteoarthritis, knee joint, synovial membrane, mesenchymal stem cells, cell surface markersmaster thesis10.11575/PRISM/25235