Mardinger, CynthiaBoiteau, Paul J. E.Kortbeek, John B.2020-05-242020-05-242020-05-20Cynthia Mardinger, Paul J. E. Boiteau, and John B. Kortbeek, “Thrombolysis of Postoperative Acute Pulmonary Embolism with a Thrombus in Transit,” Case Reports in Medicine, vol. 2020, Article ID 7561986, 5 pages, 2020. doi:10.1155/2020/7561986http://dx.doi.org/10.1155/2020/7561986http://hdl.handle.net/1880/112116https://dx.doi.org/10.11575/PRISM/37876Right heart thrombus in transit clot (RHTT) associated with a pulmonary thromboembolism (PTE) is a rare but potentially fatal diagnosis. Early diagnosis and immediate intervention are crucial. This report describes the case of a healthy, physically active 32-year-old female who presented 19 days postoperatively, following an anterior cruciate ligament reconstruction and partial lateral meniscectomy with a saddle PE, RHTT, and right ventricular (RV) strain. The patient received half of the standard dose of intravenous tissue plasminogen activator (TPA) in combination with anticoagulation and survived. Case reports of RHTT will inform future studies designed to evaluate whether and when thrombolysis should be administered.Journal Article2020-05-24enCopyright © 2020 Cynthia Mardinger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.