Kirkpatrick, Andrew WallaceDoig, Christopher JamesAl Rawahi, Aziza2019-07-152019-07-152019-07-12Al Rawahi, A. (2019). The Role of Procalcitonin Measurements in Predicting Clinical Outcomes in Critically Ill/Injured Patients (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.http://hdl.handle.net/1880/110641Background: Major trauma is associated with high incidence of septic complications and multiple organ dysfunction (MOD). We assessed the prognostic value of serum and peritoneal procalcitonin (PCT) levels after trauma. Methods: We searched electronic database and included original studies that assessed prognostic value of PCT after trauma. We performed a retrospective analysis of the Intraperitoneal Vacuum Trial to assess correlation of plasma and peritoneal levels of PCT with clinical outcomes in patients managed with the open abdomen (OA) technique. Results: Among 2,015 citations identified, 19 studies met inclusion criteria. All studies showed a strong correlation between initial PCT levels and Injury Severity Score (ISS). Initial peak PCT levels predicted development of sepsis and MOD after trauma. Conclusion: PCT seems to hold promise as a surrogate biomarker for trauma. Initial peak PCT level may be used as an early predictor of sepsis, MOD, and mortality in trauma population.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.ProcalcitoninTraumaCritical CarePrognosisOpen AbdomenNegative pressure peritoneal therapyInjuryMedicine and Surgerymaster thesishttp://dx.doi.org/10.11575/PRISM/36748