Boyd, Steven KyleMichalak, Geoffrey Jan2018-05-252018-05-252018-05-22Michalak, G. J. (2018). Concurrent Assessment of Knee Cartilage Morphology and Bone Microarchitecture using Contrast-Enhanced HR-pQCT Imaging (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/31941http://hdl.handle.net/1880/106674Osteoarthritis (OA) is a prevalent articular disease characterized by degradation of articular cartilage and bone. Presently, no single imaging modality concurrently captures these changes. This study sought to develop and validate a novel joint imaging technique, contrast enhanced high resolution peripheral quantitative computed tomography (CEHR-pQCT), to concurrently assess bone microarchitecture and cartilage morphology. Cadaveric knees were harvested (n=10) and scanned using magnetic resonance imaging (MRI), HR-pQCT without contrast, and HR- pQCT following intra-articular injection of non-ionic contrast media. Joints were disarticulated, and the articular cartilage thickness measured by needle probe. Measures of cartilage morphology were found to be significantly different between MRI, needle probing and CEHR- pQCT. Bone microarchitecture was found to be significantly different in CEHR-pQCT, where cortical bone mineral density (BMD) was depressed, and trabecular BMD increased. This study contributes toward the advancement of whole joint imaging techniques, laying the foundation to perform in vivo scanning of knee cartilage and bone.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.HR-pQCTOsteoarthritisContrast MediaCartilageBoneCEHR-pQCTMedicine and SurgeryRadiologyEngineering--Biomedicalmaster thesis10.11575/PRISM/31941