Smith, EricFrayne, RichardWang, Xinjue Rachel2015-09-022015-11-202015-09-022015Wang, X. R. (2015). Neuroimaging Biomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Patients with Subjective Cognitive Concerns and Mild Cognitive Impairment (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27084http://hdl.handle.net/11023/2421In these studies, patients with subjective cognitive concerns (SCC; n = 43) and mild cognitive impairment (MCI; n = 18), were compared using neuroimaging biomarkers for β-amyloid, white matter hyperintensities (WMH) of presumed vascular origin, and cerebral perfusion. Higher WMH burden was found in SCC compared to MCI (p = 0.02). In the whole cohort, there was a correlation between higher β-amyloid accumulation and lower left (p = 0.02) and right temporal gyrus perfusion (p = 0.05), while higher WMH burden was associated with lower perfusion in the cortical grey matter (p = 0.01), posterior cingulate cortex (p = 0.02) and right temporal gyrus (p = 0.01). Exploratory comparisons suggested lower perfusion in the left temporal gyrus and anterior cingulate cortex in amnestic MCI (n = 12) compared to non-amnestic MCI (n = 6). These findings suggest that pathologies consistent with dementia are evident in early cognitive decline.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Medicine and SurgeryMild Cognitive ImpairmentAlzheimer's DiseaseDementiaSubjective Cognitive ConcernsCerebrovascular DiseaseNeuroimagingmaster thesishttp://dx.doi.org/10.11575/PRISM/27084