Capper, Miles S.Enriquez Garcia, AlejandraLai, BarryWang, Baiwen O.Gelfand, Benjamin S.Shemanko, Carrie S.Jalilehvand, Farideh2021-07-302021-04-16Capper, M. S., Enriquez Garcia, A., Lai, B., Wang, B. O., Gelfand, B. S., Shemanko, C. S., & Jalilehvand, F. (2021). The effect of sodium thiosulfate on cytotoxicity of a diimine Re(I) tricarbonyl complex. Dalton Transactions, 50(17), 5968–5977. doi:10.1039/d1dt00517k1477-9234http://hdl.handle.net/1880/113675https://dx.doi.org/10.11575/PRISM/39046Recently, diimine Re(I) tricarbonyl complexes have attracted great interest due to their promising cytotoxic effects. Here, we compare the cytotoxicity and cellular uptake of two Re(I) compounds fac-[(Re(CO)3(bpy)(H2O)](CF3SO3) (1) and Na(fac-[(Re(CO)3(bpy)(S2O3)])·H2O (bpy = 2,2?-bipyridine) (2). The Re-thiosulfate complex in 2 was characterized in two solvated crystal structures {Na(fac-[Re(CO)3(bpy)(S2O3)])·1.75H2O·C2H5OH}4 (2 + 0.75H2O + C2H5OH)4 and (fac-[Re(CO)3(bpy)(H2O)]) (fac-[Re(CO)3(bpy)(S2O3)])·4H2O (3). The cytotoxicity of 1 and 2 was tested in the MDA-MB-231 breast cancer cell line and compared with that of cisplatin. The cellular localization of the Re(I) complexes was investigated using synchrotron-based X-ray fluorescence microscopy (XFM). The results show that replacement of the aqua ligand with thiosulfate renders the complex less toxic most likely by distrupting its cellular entry. Therefore, thiosulfate could potentially have a similar chemoprotective effect against diimine fac-Re(CO)3 complexes as it has against cisplatin.enUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.journal articleRGPIN 2016-04546RGPIN-2018-04773#300072#947910.1039/D1DT00517K