Nygren, AndersRandall, Alyssa2013-01-302013-06-152013-01-302013Randall, A. (2013). Ischemia-Reperfusion Arrhythmias and Intercellular Coupling in Diabetic and Ischemic-Preconditioned Rat Heart (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26676http://hdl.handle.net/11023/534Diabetes and Ischemic Preconditioning (IPC) have been shown in literature to have similar metabolic and microscopic effects on intercellular coupling, conduction reserve, and the response to ischemia-reperfusion in ventricular tissue. Both diabetes and IPC cause reduced intercellular coupling; reduced conduction reserve; and provide cardio-protection to ischemia/reperfusion. To determine the whole heart similarities between IPC and diabetes both electrocardiograph (ECG) and optical mapping data was evaluated. Diabetes displayed different time dependent responses to ischemia/reperfusion from IPC and healthy animals; diabetic animals slow heart rate significantly compared to IPC and control animals during ischemia, while IPC slows conduction velocity. During pacing, IPC and diabetic animals showed similar slowing of conduction velocity though only diabetic animals showed significant slowing in response to reduced cellular excitability. This work suggests IPC and diabetes do not use the same mechanisms to provide cardio-protective effects.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Animal PhysiologyEngineering--BiomedicalEngineering--Electronics and ElectricalIschemiaresperfusionDiabetesarrhythmiaischemic preconditioningmaster thesis10.11575/PRISM/26676