Browsing by Author "Abounassif, Mazen M."

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    Association between SMOFlipid and impaired brain development on term-equivalent age brain magnetic resonance imaging in very preterm infants
    (2024-10-29) Al-Mouqdad, Mountasser M.; Alshaikh, Belal; Sumaily, Haider H.; Alodhaidan, Nabeel A.; AlMahmoud, Latifah; Almotiri, Ameen A.; Alkhourmi, Mousa A.; Abounassif, Mazen M.; Beh, Ahmed F.; Alawad, Mashael A.; Albraiki, Amani A.; Alqarni, Aziza A.; Al-Anazi, Maha R.; Basodan, Nadia A.; Assiri, Fuddah M.; Asfour, Suzan S.
    Abstract Soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOFlipid) is used without evidence of benefits. We investigated the relationship between lipid emulsions and brain injury in term-equivalent age magnetic resonance imaging (MRI) in 148 very preterm infants with a birth weight of < 1500 g at ≤ 32 gestational weeks in a neonatal intensive care unit. Infants who received soybean-based lipid emulsions between January 2015 and December 2018 were compared with those who received SMOFlipids between January 2019 and December 2022. A negative binomial generalized linear model was applied for bivariate analysis. Modified log-Poisson regression with generalized linear models and a robust variance estimator (Huber–White) were applied to adjust for potential confounders. The Kidokoro score was used to determine if lipid emulsion type would affect brain morphology and growth at term-equivalent age. Eighty-six (58.9%) received SMOFlipid. SMOFlipid was associated with lower focal signal abnormality, myelination delay, increased extracerebral space, and cerebellar volume reduction (P = 0.02, P = 0.007, P = 0.01, P = 0.02, respectively). SMOFlipidis are associated with brain insult, especially in white matter, cortical gray matter, and the cerebellum. Well-designed studies are needed to investigate the effect of lipid emulsions on the central nervous system.