Browsing by Author "Ali, Syedah Salwa"

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    Predicting Thrombus Formation in Patients with Internal Carotid Artery Webs
    (2017) Ali, Syedah Salwa; Mitha, Alim P.; Di Martino, Elena; Tyberg, John V.; Egberts, Philip; Wood, David; Natale, Giovanniantonio
    Carotid webs are fibro-intimal growths affecting the internal carotid artery but are pathologically different from common atherosclerotic plaques. They cause moderate stenosis and are difficult to diagnose. However, if treated, patients present themselves again with recurrent ischemic strokes due to thrombus formation distal to the stenosis. Lack of knowledge urged the need to conduct hemodynamic analysis. This is the first study to quantify hemodynamic changes in the carotid web region. We conducted transient analysis on 3 symptomatic stroke patients with carotid webs. Carotid web region in each of the 3 carotid arteries with web was calculated with high OSI levels (0.3 approx.), low TAWSS values (less than 0.4Pa) and high RRT values. We also visualized recirculating flow behind the web during deceleration phases of cardiac cycle. All these factors reveal that carotid webs disturb blood flow patterns to cause blood stagnation, recirculation and thrombus formation to cause stroke.