Browsing by Author "Connors, Lori"

Now showing 1 - 4 of 4
  • Thumbnail Image
    ItemOpen Access
    Canadian multidisciplinary expert consensus on the use of biologics in upper airways: a Delphi study
    (2023-04-24) Thamboo, Andrew V.; Lee, Melissa; Bhutani, Mohit; Chan, Charles; Chan, Yvonne; Chapman, Ken R.; Chin, Christopher J.; Connors, Lori; Dorscheid, Del; Ellis, Anne K.; Gall, Richard M.; Godbout, Krystelle; Janjua, Arif; Javer, Amin; Kilty, Shaun; Kim, Harold; Kirkpatrick, Gordon; Lee, John M.; Leigh, Richard; Lemiere, Catherine; Monteiro, Eric; Neighbour, Helen; Keith, Paul K.; Philteos, George; Quirt, Jaclyn; Rotenberg, Brian; Ruiz, Juan C.; Scott, John R.; Sommer, Doron D.; Sowerby, Leigh; Tewfik, Marc; Waserman, Susan; Witterick, Ian; Wright, Erin D.; Yamashita, Cory; Desrosiers, Martin
    Abstract Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) often coexists with lower airway disease. With the overlap between upper and lower airway disease, optimal management of the upper airways is undertaken in conjunction with that of the lower airways. Biologic therapy with targeted activity within the Type 2 inflammatory pathway can improve the clinical signs and symptoms of both upper and lower airway diseases. Knowledge gaps nevertheless exist in how best to approach patient care as a whole. There have been sixteen randomized, double-blind, placebo-controlled trails performed for CRSwNP targeted components of the Type 2 inflammatory pathway, notably interleukin (IL)-4, IL-5 and IL-13, IL- 5R, IL-33, and immunoglobulin (Ig)E. This white paper considers the perspectives of experts in various disciplines such as rhinology, allergy, and respirology across Canada, all of whom have unique and valuable insights to contribute on how to best approach patients with upper airway disease from a multidisciplinary perspective. Methods A Delphi Method process was utilized involving three rounds of questionnaires in which the first two were completed individually online and the third was discussed on a virtual platform with all the panelists. A national multidisciplinary expert panel of 34 certified specialists was created, composed of 16 rhinologists, 7 allergists, and 11 respirologists who evaluated the 20 original statements on a scale of 1–9 and provided comments. All ratings were quantitively reviewed by mean, median, mode, range, standard deviation and inter-rater reliability. Consensus was defined by relative interrater reliability measures—kappa coefficient ( $$\kappa$$ κ ) value > 0.61. Results After three rounds, a total of 22 statements achieved consensus. This white paper only contains the final agreed upon statements and clear rationale and support for the statements regarding the use of biologics in patients with upper airway disease. Conclusion This white paper provides guidance to Canadian physicians on the use of biologic therapy for the management of upper airway disease from a multidisciplinary perspective, but the medical and surgical regimen should ultimately be individualized to the patient. As more biologics become available and additional trials are published we will provide updated versions of this white paper every few years. Graphical abstract
  • Thumbnail Image
    ItemOpen Access
    Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016
    (2017-04-07) Alsayegh, Mohammad A; Alshamali, Hanan; Khadada, Mousa; Ciccolini, Amanda; Ellis, Anne K; Quint, Diana; Powley, William; Lee, Laurie; Fiteih, Yahya; Baksh, Shairaz; Vliagoftis, Harissios; Gerega, Sebastien K; Millson, Brad; Charland, Katia; Barakat, Stephane; Sun, Xichun; Jimenez, Ricardo; Waserman, Susan; FitzGerald, Mark J; Hébert, Jacques; Cognet-Sicé, Josiane; Renahan, Kevin E; Huq, Saiful; Chooniedass, Rishma; Sawyer, Scott; Pasterkamp, Hans; Becker, Allan; Smith, Steven G; Zhang, Shiyuan; Jayasundara, Kavisha; Tacon, Claire; Simidchiev, Alex; Nadeau, Gilbert; Gunsoy, Necdet; Mullerova, Hana; Albers, Frank; Kim, Young W; Shannon, Casey P; Singh, Amrit; Neighbour, Helen; Larché, Mark; Tebbutt, Scott J; Klopp, Annika; Vehling, Lorena; Becker, Allan B; Subbarao, Padmaja; Mandhane, Piushkumar J; Turvey, Stuart E; Sears, Malcolm R; Azad, Meghan B; Loewen, Keely; Monchka, Barret; Mahmud, Salaheddin M; Jong, Geert ‘; Longo, Cristina; Bartlett, Gillian; Ducharme, Francine M; Schuster, Tibor; MacGibbon, Brenda; Barnett, Tracie; North, Michelle L; Brook, Jeff; Lee, Elizabeth; Omana, Vanessa; Thiele, Jenny; Steacy, Lisa M; Evans, Greg; Diamond, Miriam; Sussman, Gordon L; Amistani, Yann; Abiteboul, Kathy; Tenn, Mark W; Yang, ChenXi; Carlsten, Christopher; Conway, Edward M; Mack, Douglas; Othman, Yasmin; Barber, Colin M; Kalicinsky, Chrystyna; Burke, Andrea E; Messieh, Mary; Nair, Parameswaran; Che, Chun T; Douglas, Lindsay; Liem, Joel; Duan, Lucy; Miller, Charlotte; Dupuis, Pascale; Connors, Lori A; Fein, Michael N; Shuster, Joseph; Hadi, Hani; Polk, Brooke; Raje, Nikita; Labrosse, Roxane; Bégin, Philippe; Paradis, Louis; Roches, Anne D; Lacombe-Barrios, Jonathan; Mishra, Sanju; Lacuesta, Gina; Chiasson, Meredith; Haroon, Babar; Robertson, Kara; Issekutz, Thomas; Leddin, Desmond; Couban, Stephen; Connors, Lori; Roos, Adrienne; Kanani, Amin; Chan, Edmond S; Schellenberg, Robert; Rosenfield, Lana; Cvetkovic, Anna; Woodward, Kevin; Quirt, Jaclyn; Watson, Wade T A; Castilho, Edson; Sullivan, Jennifer A; Temple, Beverley; Martin, Donna; Cook, Victoria E; Mills, Christopher; Portales-Casamar, Elodie; Fu, Lisa W; Ho, Alexander; Zaltzman, Jeffrey; Chen, Lucy; Vadas, Peter; Gabrielli, Sofianne; Clarke, Ann; Eisman, Harley; Morris, Judy; Joseph, Lawrence; LaVieille, Sebastien; Ben-Shoshan, Moshe; Graham, François; Barnes, Charles; Portnoy, Jay; Stagg, Vincent; Simons, Elinor; Lefebvre, Diana; Dai, David; Mandhane, Piushkumar; Sears, Malcolm; Tam, Herman; Simons, F. E R; Alotaibi, Dhaifallah; Dawod, Bassel; Tunis, Matthew C; Marshall, Jean; Desjardins, Marylin; Béland, Marianne; Lejtenyi, Duncan; Drolet, Jean-Phillipe; Lemire, Martine; Tsoukas, Christos; Noya, Francisco J; Alizadehfar, Reza; McCusker, Christine T; Mazer, Bruce D; Maestre-Batlle, Danay; Gunawan, Evelyn; Rider, Christopher F; Bølling, Anette K; Pena, Olga M; Suez, Daniel; Melamed, Isaac; Hussain, Iftikhar; Stein, Mark; Gupta, Sudhir; Paris, Kenneth; Fritsch, Sandor; Bourgeois, Christelle; Leibl, Heinz; McCoy, Barbara; Noel, Martin; Yel, Leman; Scott, Ori; Reid, Brenda; Atkinson, Adelle; Kim, Vy H; Roifman, Chaim M; Grunebaum, Eyal; AlSelahi, Eiman; Aleman, Fernando; Oberle, Amber; Trus, Mike; Sussman, Gordon; Kanani, Amin S; Chambenoi, Olivier; Chiva-Razavi, Sima; Grodecki, Savannah; Joshi, Nikhil; Menikefs, Peter; Holt, David; Pun, Teresa; Tworek, Damian; Hanna, Raphael; Heroux, Delia; Rosenberg, Elli; Stiemsma, Leah; Turvey, Stuart; Denburg, Judah; Mill, Christopher; Teoh, Timothy; Zimmer, Preeti; Avinashi, Vishal; Paina, Mihaela; Darwish Hassan, Ahmed A; Oliveria, John P; Olesovsky, Chris; Gauvreau, Gail; Pedder, Linda; Keith, Paul K; Plunkett, Greg; Bolner, Michelle; Pourshahnazari, Persia; Stark, Donald; Vostretsova, Kateryna; Moses, Andrew; Wakeman, Andrew; Singer, Alexander; Gerstner, Thomas; Abrams, Elissa; Johnson, Sara F; Woodgate, Roberta L
  • Thumbnail Image
    ItemOpen Access
    Correction to: The International/Canadian Hereditary Angioedema Guideline
    (2020-05-06) Betschel, Stephen; Badiou, Jacquie; Binkley, Karen; Borici-Mazi, Rozita; Hébert, Jacques; Kanani, Amin; Keith, Paul; Lacuesta, Gina; Waserman, Susan; Yang, Bill; Aygören-Pürsün, Emel; Bernstein, Jonathan; Bork, Konrad; Caballero, Teresa; Cicardi, Marco; Craig, Timothy; Farkas, Henriette; Grumach, Anete; Katelaris, Connie; Longhurst, Hilary; Riedl, Marc; Zuraw, Bruce; Berger, Magdelena; Boursiquot, Jean-Nicolas; Boysen, Henrik; Castaldo, Anthony; Chapdelaine, Hugo; Connors, Lori; Fu, Lisa; Goodyear, Dawn; Haynes, Alison; Kamra, Palinder; Kim, Harold; Lang-Robertson, Kelly; Leith, Eric; McCusker, Christine; Moote, Bill; O’Keefe, Andrew; Othman, Ibraheem; Poon, Man-Chiu; Ritchie, Bruce; St-Pierre, Charles; Stark, Donald; Tsai, Ellie
    An amendment to this paper has been published and can be accessed via the original article.
  • Thumbnail Image
    ItemOpen Access
    The International/Canadian Hereditary Angioedema Guideline
    (2019-11-25) Betschel, Stephen; Badiou, Jacquie; Binkley, Karen; Borici-Mazi, Rozita; Hébert, Jacques; Kanani, Amin; Keith, Paul; Lacuesta, Gina; Waserman, Susan; Yang, Bill; Aygören-Pürsün, Emel; Bernstein, Jonathan; Bork, Konrad; Caballero, Teresa; Cicardi, Marco; Craig, Timothy; Farkas, Henriette; Grumach, Anete; Katelaris, Connie; Longhurst, Hilary; Riedl, Marc; Zuraw, Bruce; Berger, Magdelena; Boursiquot, Jean-Nicolas; Boysen, Henrik; Castaldo, Anthony; Chapdelaine, Hugo; Connors, Lori; Fu, Lisa; Goodyear, Dawn; Haynes, Alison; Kamra, Palinder; Kim, Harold; Lang-Robertson, Kelly; Leith, Eric; McCusker, Christine; Moote, Bill; O’Keefe, Andrew; Othman, Ibraheem; Poon, Man-Chiu; Ritchie, Bruce; St-Pierre, Charles; Stark, Donald; Tsai, Ellie
    Abstract This is an update to the 2014 Canadian Hereditary Angioedema Guideline with an expanded scope to include the management of hereditary angioedema (HAE) patients worldwide. It is a collaboration of Canadian and international HAE experts and patient groups led by the Canadian Hereditary Angioedema Network. The objective of this guideline is to provide evidence-based recommendations, using the GRADE system, for the management of patients with HAE. This includes the treatment of attacks, short-term prophylaxis, long-term prophylaxis, and recommendations for self-administration, individualized therapy, quality of life, and comprehensive care. New to the 2019 version of this guideline are sections covering the diagnosis and recommended therapies for acute treatment in HAE patients with normal C1-INH, as well as sections on pregnant and paediatric patients, patient associations and an HAE registry. Hereditary angioedema results in random and often unpredictable attacks of painful swelling typically affecting the extremities, bowel mucosa, genitals, face and upper airway. Attacks are associated with significant functional impairment, decreased health-related quality of life, and mortality in the case of laryngeal attacks. Caring for patients with HAE can be challenging due to the complexity of this disease. The care of patients with HAE in Canada, as in many countries, continues to be neither optimal nor uniform. It lags behind some other countries where there are more organized models for HAE management, and greater availability of additional licensed therapeutic options. It is anticipated that providing this guideline to caregivers, policy makers, patients, and advocates will not only optimize the management of HAE, but also promote the importance of individualized care. The primary target users of this guideline are healthcare providers who are managing patients with HAE. Other healthcare providers who may use this guideline are emergency and intensive care physicians, primary care physicians, gastroenterologists, dentists, otolaryngologists, paediatricians, and gynaecologists who will encounter patients with HAE and need to be aware of this condition. Hospital administrators, insurers and policy makers may also find this guideline helpful.