Browsing by Author "Field, Nicholas C."
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- ItemOpen AccessMetastatic Transitional Cell Carcinoma of the Bladder to the Testis: A Case Report(2012-10-22) Kozak, Gregory N.; Field, Nicholas C.An 84-year-old gentleman presented with onset of gross hematuria in September 2010. Follow-up investigations revealed T1 superficially invasive, poorly differentiated, papillary urothelial carcinoma. He subsequently had GreenLight laser for BPH and bladder neck contracture on two occasions. He developed a right hydrocele 16 months after initial presentation and during his hydrocelectomy, a rock-hard right epididymis and testicle were discovered. Pathology revealed metastatic urothelial carcinoma replacing nearly the entire testis with lymphovascular invasion.
- ItemOpen AccessThe Use of Regenerative Medicine in the Management of Invasive Bladder Cancer(2012-08-27) Hyndman, Matthew E.; Kaye, Deborah; Field, Nicholas C.; Lawson, Keith A.; Smith, Norm D.; Steinberg, Gary D.; Schoenberg, Mark P.; Bivalacqua, Trinity J.Muscle invasive and recurrent nonmuscle invasive bladder cancers have been traditionally treated with a radical cystectomy and urinary diversion. The urinary diversion is generally accomplished through the creation of an incontinent ileal conduit, continent catheterizable reservoir, or orthotopic neobladder utilizing small or large intestine. While radical extirpation of the bladder is often successful from an oncological perspective, there is a significant morbidity associated with enteric interposition within the genitourinary tract. Therefore, there is a great opportunity to decrease the morbidity of the surgical management of bladder cancer through utilization of novel technologies for creating a urinary diversion without the use of intestine. Clinical trials using neourinary conduits (NUC) seeded with autologous smooth muscle cells are currently in progress and may represent a significant surgical advance, potentially eliminating the complications associated with the use of gastrointestinal segments in the urinary reconstruction, simplifying the surgical procedure, and greatly facilitating recovery from cystectomy.
- ItemOpen AccessThe Use of Regenerative Medicine in the Management of Invasive Bladder Cancer(Hindawi Publishing Corporation, 2012-08-01) Hyndman, Matthew E.; Kaye, Deborah; Field, Nicholas C.; Lawson, Keith A.; Smith, Norm D.; Steinberg, Gary D.; Schoenberg, Mark P.; Bivalacqua, Trinity J.