Browsing by Author "Huang, Jing"

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    Exploration on Just Noticeable Difference of Amplitude for Surface Shape Perception in a VE through Haptic Interactions
    (2021-11-25) Huang, Jing; Hu, Yaoping; Fear, Elise C.; Krishnamurthy, Diwakar
    Human ability to perceive surface shapes plays a crucial role in understanding their surrounding objects and environments. Although the sense of vision has been employed frequently for virtual shape perception, it is desirable to enhance performance of shape perception in the three-dimensional (3D) virtual environments (VEs) by providing haptic feedback. To explore how well the human ability is to discriminate surface shapes under haptic feedback, the experiment presented in this thesis applied a novel force model, which was created by our research lab, to distinguish four kinds of sinusoidal virtual surfaces, which have various amplitudes differing from a flat surface. The main finding is that Just Noticeable Difference (JND) range of amplitude was around 1.19 - 1.95 mm for distinguishing sinusoidal virtual surfaces from flat ones. This finding quantifies the human ability to discriminate virtual surfaces, and may contribute to fundamental knowledge for creating applications with haptic interactions.
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    PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial
    (2021-11-06) Weiss, Scott L.; Balamuth, Fran; Long, Elliot; Thompson, Graham C.; Hayes, Katie L.; Katcoff, Hannah; Cook, Marlena; Tsemberis, Elena; Hickey, Christopher P.; Williams, Amanda; Williamson-Urquhart, Sarah; Borland, Meredith L.; Dalziel, Stuart R.; Gelbart, Ben; Freedman, Stephen B.; Babl, Franz E.; Huang, Jing; Kuppermann, Nathan
    Abstract Background/aims Despite evidence that preferential use of balanced/buffered fluids may improve outcomes compared with chloride-rich 0.9% saline, saline remains the most commonly used fluid for children with septic shock. We aim to determine if resuscitation with balanced/buffered fluids as part of usual care will improve outcomes, in part through reduced kidney injury and without an increase in adverse effects, compared to 0.9% saline for children with septic shock. Methods The Pragmatic Pediatric Trial of Balanced versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) study is an international, open-label pragmatic interventional trial being conducted at > 40 sites in the USA, Canada, and Australia/New Zealand starting on August 25, 2020, and continuing for 5 years. Children > 6 months to < 18 years treated for suspected septic shock with abnormal perfusion in an emergency department will be randomized to receive either balanced/buffered crystalloids (intervention) or 0.9% saline (control) for initial resuscitation and maintenance fluids for up to 48 h. Eligible patients are enrolled and randomized using serially numbered, opaque envelopes concurrent with clinical care. Given the life-threatening nature of septic shock and narrow therapeutic window to start fluid resuscitation, patients may be enrolled under “exception from informed consent” in the USA or “deferred consent” in Canada and Australia/New Zealand. Other than fluid type, all decisions about timing, volume, and rate of fluid administration remain at the discretion of the treating clinicians. For pragmatic reasons, clinicians will not be blinded to study fluid type. Anticipated enrollment is 8800 patients. The primary outcome will be major adverse kidney events within 30 days (MAKE30), a composite of death, renal replacement therapy, and persistent kidney dysfunction. Additional effectiveness, safety, and biologic outcomes will also be analyzed. Discussion PRoMPT BOLUS will provide high-quality evidence for the comparative effectiveness of buffered/balanced crystalloids versus 0.9% saline for the initial fluid management of children with suspected septic shock in emergency settings. Trial registration PRoMPT BOLUS was first registered at ClinicalTrials.gov ( NCT04102371 ) on September 25, 2019. Enrollment started on August 25, 2020.