Browsing by Author "Kanani, Amin"

Now showing 1 - 5 of 5
  • Thumbnail Image
    ItemOpen Access
    Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016
    (2017-04-07) Alsayegh, Mohammad A; Alshamali, Hanan; Khadada, Mousa; Ciccolini, Amanda; Ellis, Anne K; Quint, Diana; Powley, William; Lee, Laurie; Fiteih, Yahya; Baksh, Shairaz; Vliagoftis, Harissios; Gerega, Sebastien K; Millson, Brad; Charland, Katia; Barakat, Stephane; Sun, Xichun; Jimenez, Ricardo; Waserman, Susan; FitzGerald, Mark J; Hébert, Jacques; Cognet-Sicé, Josiane; Renahan, Kevin E; Huq, Saiful; Chooniedass, Rishma; Sawyer, Scott; Pasterkamp, Hans; Becker, Allan; Smith, Steven G; Zhang, Shiyuan; Jayasundara, Kavisha; Tacon, Claire; Simidchiev, Alex; Nadeau, Gilbert; Gunsoy, Necdet; Mullerova, Hana; Albers, Frank; Kim, Young W; Shannon, Casey P; Singh, Amrit; Neighbour, Helen; Larché, Mark; Tebbutt, Scott J; Klopp, Annika; Vehling, Lorena; Becker, Allan B; Subbarao, Padmaja; Mandhane, Piushkumar J; Turvey, Stuart E; Sears, Malcolm R; Azad, Meghan B; Loewen, Keely; Monchka, Barret; Mahmud, Salaheddin M; Jong, Geert ‘; Longo, Cristina; Bartlett, Gillian; Ducharme, Francine M; Schuster, Tibor; MacGibbon, Brenda; Barnett, Tracie; North, Michelle L; Brook, Jeff; Lee, Elizabeth; Omana, Vanessa; Thiele, Jenny; Steacy, Lisa M; Evans, Greg; Diamond, Miriam; Sussman, Gordon L; Amistani, Yann; Abiteboul, Kathy; Tenn, Mark W; Yang, ChenXi; Carlsten, Christopher; Conway, Edward M; Mack, Douglas; Othman, Yasmin; Barber, Colin M; Kalicinsky, Chrystyna; Burke, Andrea E; Messieh, Mary; Nair, Parameswaran; Che, Chun T; Douglas, Lindsay; Liem, Joel; Duan, Lucy; Miller, Charlotte; Dupuis, Pascale; Connors, Lori A; Fein, Michael N; Shuster, Joseph; Hadi, Hani; Polk, Brooke; Raje, Nikita; Labrosse, Roxane; Bégin, Philippe; Paradis, Louis; Roches, Anne D; Lacombe-Barrios, Jonathan; Mishra, Sanju; Lacuesta, Gina; Chiasson, Meredith; Haroon, Babar; Robertson, Kara; Issekutz, Thomas; Leddin, Desmond; Couban, Stephen; Connors, Lori; Roos, Adrienne; Kanani, Amin; Chan, Edmond S; Schellenberg, Robert; Rosenfield, Lana; Cvetkovic, Anna; Woodward, Kevin; Quirt, Jaclyn; Watson, Wade T A; Castilho, Edson; Sullivan, Jennifer A; Temple, Beverley; Martin, Donna; Cook, Victoria E; Mills, Christopher; Portales-Casamar, Elodie; Fu, Lisa W; Ho, Alexander; Zaltzman, Jeffrey; Chen, Lucy; Vadas, Peter; Gabrielli, Sofianne; Clarke, Ann; Eisman, Harley; Morris, Judy; Joseph, Lawrence; LaVieille, Sebastien; Ben-Shoshan, Moshe; Graham, François; Barnes, Charles; Portnoy, Jay; Stagg, Vincent; Simons, Elinor; Lefebvre, Diana; Dai, David; Mandhane, Piushkumar; Sears, Malcolm; Tam, Herman; Simons, F. E R; Alotaibi, Dhaifallah; Dawod, Bassel; Tunis, Matthew C; Marshall, Jean; Desjardins, Marylin; Béland, Marianne; Lejtenyi, Duncan; Drolet, Jean-Phillipe; Lemire, Martine; Tsoukas, Christos; Noya, Francisco J; Alizadehfar, Reza; McCusker, Christine T; Mazer, Bruce D; Maestre-Batlle, Danay; Gunawan, Evelyn; Rider, Christopher F; Bølling, Anette K; Pena, Olga M; Suez, Daniel; Melamed, Isaac; Hussain, Iftikhar; Stein, Mark; Gupta, Sudhir; Paris, Kenneth; Fritsch, Sandor; Bourgeois, Christelle; Leibl, Heinz; McCoy, Barbara; Noel, Martin; Yel, Leman; Scott, Ori; Reid, Brenda; Atkinson, Adelle; Kim, Vy H; Roifman, Chaim M; Grunebaum, Eyal; AlSelahi, Eiman; Aleman, Fernando; Oberle, Amber; Trus, Mike; Sussman, Gordon; Kanani, Amin S; Chambenoi, Olivier; Chiva-Razavi, Sima; Grodecki, Savannah; Joshi, Nikhil; Menikefs, Peter; Holt, David; Pun, Teresa; Tworek, Damian; Hanna, Raphael; Heroux, Delia; Rosenberg, Elli; Stiemsma, Leah; Turvey, Stuart; Denburg, Judah; Mill, Christopher; Teoh, Timothy; Zimmer, Preeti; Avinashi, Vishal; Paina, Mihaela; Darwish Hassan, Ahmed A; Oliveria, John P; Olesovsky, Chris; Gauvreau, Gail; Pedder, Linda; Keith, Paul K; Plunkett, Greg; Bolner, Michelle; Pourshahnazari, Persia; Stark, Donald; Vostretsova, Kateryna; Moses, Andrew; Wakeman, Andrew; Singer, Alexander; Gerstner, Thomas; Abrams, Elissa; Johnson, Sara F; Woodgate, Roberta L
  • Thumbnail Image
    ItemOpen Access
    Correction to: The International/Canadian Hereditary Angioedema Guideline
    (2020-05-06) Betschel, Stephen; Badiou, Jacquie; Binkley, Karen; Borici-Mazi, Rozita; Hébert, Jacques; Kanani, Amin; Keith, Paul; Lacuesta, Gina; Waserman, Susan; Yang, Bill; Aygören-Pürsün, Emel; Bernstein, Jonathan; Bork, Konrad; Caballero, Teresa; Cicardi, Marco; Craig, Timothy; Farkas, Henriette; Grumach, Anete; Katelaris, Connie; Longhurst, Hilary; Riedl, Marc; Zuraw, Bruce; Berger, Magdelena; Boursiquot, Jean-Nicolas; Boysen, Henrik; Castaldo, Anthony; Chapdelaine, Hugo; Connors, Lori; Fu, Lisa; Goodyear, Dawn; Haynes, Alison; Kamra, Palinder; Kim, Harold; Lang-Robertson, Kelly; Leith, Eric; McCusker, Christine; Moote, Bill; O’Keefe, Andrew; Othman, Ibraheem; Poon, Man-Chiu; Ritchie, Bruce; St-Pierre, Charles; Stark, Donald; Tsai, Ellie
    An amendment to this paper has been published and can be accessed via the original article.
  • Thumbnail Image
    ItemOpen Access
    International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    (BioMed Central, 2010-07-28) Bowen, Tom; Cicardi, Marco; Farkas, Henriette; Bork, Konrad; Longhurst, Hilary J.; Zuraw, Bruce; Aygoeren-Pürsün, Emel; Craig, Timothy; Binkley, Karen; Hebert, Jacques; Ritchie, Bruce; Bouillet, Laurence; Betschel, Stephen; Cogar, Della; Dean, John; Devaraj, Ramachand; Hamed, Azza; Kamra, Palinder; Keith, Paul K.; Lacuesta, Gina; Leith, Eric; Lyons, Harriet; Mace, Sean; Mako, Barbara; Neurath, Doris; Poon, Man-Chiu; Rivard, Georges-Etienne; Schellenberg, Robert; Rowan, Dereth; Rowe, Anne; Stark, Donald; Sur, Smeeksha; Tsai, Ellie; Warrington, Richard; Waserman, Susan; Ameratunga, Rohan; Bernstein, Jonathan; Björkander, Janne; Brosz, Kristylea; Brosz,John; Bygum, Anette; Caballero, Teresa; Mike, Frank,; Fust, George; Harmat, George; Kanani, Amin; Kreuz, Wolfhart; Levi, Marcel; Li, Henry; Martinez-Saguer, Inmaculada; Moldovan, Dumitru; Nagy, Istvan; Nielsen, Erik W.; Nordenfelt, Patrik; Reshef, Avner; Rusicke, Eva; Smith-Foltz, Sarah; Späth, Peter; Varga, Lilian; Xiang, Zhi Yu
  • Thumbnail Image
    ItemOpen Access
    Real-world outcomes of patients with hereditary angioedema with normal C1-inhibitor function and patients with idiopathic angioedema of unknown etiology in Canada
    (2024-09-27) Adatia, Adil; Boursiquot, Jean-Nicolas; Goodyear, Dawn; Kalicinsky, Chrystyna; Kanani, Amin; Waserman, Susan; Nguyen, Michelle M. L.; Wadhwa, Abhinav; Weiss, Jessica; El-Zoeiby, Ahmed; Betschel, Stephen
    Abstract Background Hereditary angioedema with normal C1-inhibitor function (HAE nC1-INH) and idiopathic angioedema of unknown etiology (AE-UNK) are rare conditions that cause recurrent subcutaneous and submucosal swelling. The characteristics and clinical outcomes of patients with these conditions in Canada have not been studied. Methods The aim of this study was to extract real-world evidence from the electronic health records of patients with HAE nC1-INH or AE-UNK who were managed in selected practices of Canadian HAE-treating specialist physicians between 01-Jan-2012 and 01-Jan-2022, to examine case numbers, treatment, clinical outcomes, and healthcare utilization. Results Of 60 patients (37 with HAE nC1-INH, 23 with AE-UNK), median (range) age at symptom onset was 21.5 (5.0–57.0) and 23.0 (10.0–54.0) years, respectively. Time to diagnosis from onset of symptoms was 7.0 (0.0–43.0) and 2.0 (− 10.0 to 50.0) years. Significant differences were observed in terms of the predominant triggers for angioedema attacks between patients with HAE nC1-INH and AE-UNK: stress (65% vs. 26%, p = 0.007) and estrogen therapy (35% vs. 9%, p = 0.031). Before diagnosis, most patients received antihistamines (50% of HAE nC1-INH and 61% of AE-UNK patients). Post-diagnosis, 73% and 74% of HAE nC1-INH and AE-UNK patients received long-term prophylaxis (LTP), with the most common LTP treatments being subcutaneous pdC1-INH (43% of HAE nC1-INH patients and 39% of AE-UNK patients) and tranexamic acid (41% of HAE nC1-INH patients and 35% of AE-UNK patients). Of patients with HAE nC1-INH, and patients with AE-UNK, 22% and 13%, respectively, were taking more than one LTP treatment concurrently. Before HAE treatment initiation, significantly fewer patients with AE-UNK compared to patients with HAE nC1-INH had angioedema attacks affecting their extremities (13% vs. 38%, p = 0.045) and GI system (22% vs. 57%, p = 0.015). In the three months following treatment initiation, patients with AE-UNK experienced significantly fewer angioedema attacks compared to patients with HAE nC1-INH (median 2.0 attacks [0.0–48.0] vs. 6.0 attacks [0.0–60.0], p = 0.044). Additionally, fewer patients with AE-UNK compared to HAE nC1-INH experienced attacks affecting their GI system (26% vs. 57%, p = 0.032). Attack duration and frequency significantly decreased for patients with HAE nC1-INH from a median of 1.00 day (range: 0.00–7.00) to 0.29 day (range: 0.02–4.00; p = 0.001) and from 10.50 attacks (range: 0.00–90.00) to 6.00 attacks (range: 0.00–60.00; p = 0.004) in the three months following HAE treatment initiation. Conclusions Using Canadian real-world evidence, these data demonstrate differing clinical trajectories between patients with HAE nC1-INH and AE-UNK, including diagnostic delays, varied attack characteristics, treatment responses and healthcare utilization. Despite treatment response, many patients still experienced frequent angioedema attacks. These results suggest an unmet need for treatment guidelines and therapies specifically for patients with HAE nC1-INH and AE-UNK and better understanding of the pathophysiology accounting for the reported differences between the two.
  • Thumbnail Image
    ItemOpen Access
    The International/Canadian Hereditary Angioedema Guideline
    (2019-11-25) Betschel, Stephen; Badiou, Jacquie; Binkley, Karen; Borici-Mazi, Rozita; Hébert, Jacques; Kanani, Amin; Keith, Paul; Lacuesta, Gina; Waserman, Susan; Yang, Bill; Aygören-Pürsün, Emel; Bernstein, Jonathan; Bork, Konrad; Caballero, Teresa; Cicardi, Marco; Craig, Timothy; Farkas, Henriette; Grumach, Anete; Katelaris, Connie; Longhurst, Hilary; Riedl, Marc; Zuraw, Bruce; Berger, Magdelena; Boursiquot, Jean-Nicolas; Boysen, Henrik; Castaldo, Anthony; Chapdelaine, Hugo; Connors, Lori; Fu, Lisa; Goodyear, Dawn; Haynes, Alison; Kamra, Palinder; Kim, Harold; Lang-Robertson, Kelly; Leith, Eric; McCusker, Christine; Moote, Bill; O’Keefe, Andrew; Othman, Ibraheem; Poon, Man-Chiu; Ritchie, Bruce; St-Pierre, Charles; Stark, Donald; Tsai, Ellie
    Abstract This is an update to the 2014 Canadian Hereditary Angioedema Guideline with an expanded scope to include the management of hereditary angioedema (HAE) patients worldwide. It is a collaboration of Canadian and international HAE experts and patient groups led by the Canadian Hereditary Angioedema Network. The objective of this guideline is to provide evidence-based recommendations, using the GRADE system, for the management of patients with HAE. This includes the treatment of attacks, short-term prophylaxis, long-term prophylaxis, and recommendations for self-administration, individualized therapy, quality of life, and comprehensive care. New to the 2019 version of this guideline are sections covering the diagnosis and recommended therapies for acute treatment in HAE patients with normal C1-INH, as well as sections on pregnant and paediatric patients, patient associations and an HAE registry. Hereditary angioedema results in random and often unpredictable attacks of painful swelling typically affecting the extremities, bowel mucosa, genitals, face and upper airway. Attacks are associated with significant functional impairment, decreased health-related quality of life, and mortality in the case of laryngeal attacks. Caring for patients with HAE can be challenging due to the complexity of this disease. The care of patients with HAE in Canada, as in many countries, continues to be neither optimal nor uniform. It lags behind some other countries where there are more organized models for HAE management, and greater availability of additional licensed therapeutic options. It is anticipated that providing this guideline to caregivers, policy makers, patients, and advocates will not only optimize the management of HAE, but also promote the importance of individualized care. The primary target users of this guideline are healthcare providers who are managing patients with HAE. Other healthcare providers who may use this guideline are emergency and intensive care physicians, primary care physicians, gastroenterologists, dentists, otolaryngologists, paediatricians, and gynaecologists who will encounter patients with HAE and need to be aware of this condition. Hospital administrators, insurers and policy makers may also find this guideline helpful.