Browsing by Author "Shysh, Andrea Christine"

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    Incidence and Risk Factors for Hyponatremia in Patients Newly Prescribed Citalopram
    (2019-04-26) Shysh, Andrea Christine; Naugler, Christopher T.; Sidhu, Davinder; Ismail, Zahinoor
    Hyponatremia is a common and under-recognized adverse drug reaction of citalopram. This study aims to determine the incidence of hyponatremia and to identify risk factors in a large, population-based cohort initiating new prescriptions for citalopram. Following approval from the ethics review board, data were obtained from Alberta Information Network databases to identify patients with new citalopram prescriptions from 2010-2017, inclusive. Hyponatremia was defined as serum sodium level <135 mmol/L. Associations were determined by performing Cox regression with time-varying covariate analysis, with the development of hyponatremia as the dependent variable. This is the first large-scale, population-based study to explore risk factors, based solely on laboratory serum data, for the development of hyponatremia in patients initiating citalopram therapy. We report a 16.7% incidence of hyponatremia after starting citalopram treatment and significant risk factors include lower baseline sodium, concurrent thiazide diuretic use, older age, and male sex.