Browsing by Author "Switzer, Aaron"

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    Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
    (2014-08-15) Switzer, Aaron; Smith, Eric; Goodyear, Bradley
    Cerebral amyloid angiopathy (CAA) refers to the deposition of Abeta (Aβ) peptides in the brains small blood vessels leading to hemorrhagic stroke and cognitive impairment. Aβ is toxic to smooth muscle cells and impairs blood flow regulation. Reduced blood oxygen level dependent (BOLD) signal amplitude in response to a visual fMRI task has recently been implicated as a surrogate marker for impaired vascular reactivity in CAA. There have been no studies investigating how the BOLD amplitude changes in other Aβ diseases that present with CAA (Alzheimer’s disease (AD) or mild cognitive impairment (MCI)), or how it changes over time in CAA. BOLD amplitudes were lowest in CAA compared to controls but were not lower in MCI or AD. BOLD amplitudes decreased over 1-year in CAA but not in controls. These results provide more evidence for the use of BOLD amplitudes as a measure of impaired vascular reactivity in CAA.