Browsing by Author "Vanderkooi, Otto"
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- ItemOpen AccessAntimicrobial Use Over a Four-Year Period Using Days of Therapy Measurement at a Canadian Pediatric Acute Care Hospital(2015-01-01) Dalton, Bruce R; MacTavish, Sandra J; Bresee, Lauren C; Rajapakse, Nipunie; Vanderkooi, Otto; Vayalumkal, Joseph; Conly, JohnBACKGROUND: Antimicrobial resistance is a concern that is challenging the ability to treat common infections. Surveillance of antimicrobial use in pediatric acute care institutions is complicated because the common metric unit, the defined daily dose, is problematic for this population.OBJECTIVE: During a four-year period in which no specific antimicrobial stewardship initiatives were conducted, pediatric antimicrobial use was quantified using days of therapy (DOT) per 100 patient days (PD) (DOT/100 PD) at the Alberta Children’s Hospital (Calgary, Alberta) for benchmarking purposes.METHODS: Drug use data for systemic antimicrobials administered on wards at the Alberta Children’s Hospital were collected from electronic medication administration records. DOT were calculated and rates were determined using 100 PD as the denominator. Changes over the surveillance period and subgroup proportions were represented graphically and assessed using linear regression.RESULTS: Total antimicrobial use decreased from 93.6 DOT/100 PD to 75.7 DOT/100 PD (19.1%) over the 2010/2011 through to the 2013/2014 fiscal years. During this period, a 20.0% increase in PD and an essentially stable absolute count of DOT (2.9% decrease) were observed. Overall, antimicrobial use was highest in the pediatric intensive care and oncology units.DISCUSSION: The exact changes in prescribing patterns that led to the observed reduction in DOT/100 PD with associated increased PD are unclear, but may be a topic for future investigations.CONCLUSION: Antimicrobial use data from a Canadian acute care pediatric hospital reported in DOT/100 PD were compiled for a four-year time period. These data may be useful for benchmarking purposes.
- ItemOpen AccessImmune Response in Young Men to the 2014/15 Seasonal Influenza Vaccine(2016-02-04) Stewart, Andrew; Doyle-Baker, Patricia Katherine; Reimer, Raylene; Vanderkooi, OttoCurrently there is limited research on the impact of adiposity and physical activity on influenza vaccination. The purpose of this pilot study was to investigate the role of adiposity and physical activity in the immune response of males aged 18-35 to the 2014/2015 seasonal trivalent influenza vaccine. Blood was drawn pre and four weeks post vaccination. Serum samples were analyzed for changes in antibody titers, serum leptin, soluble leptin receptors (sLEPR) and C-reactive protein (CRP). No differences in median percent body fat, leptin, sLEPR or CRP were associated with seroconversion rates. Participants with higher physical activity scores had lower seroconversion rates. Differences were found for the A/Texas strain (p<0.01) with a similar trend observed for the other influenza strains. Further work needs to be done in this area to confirm this trend.