Veterinary Medicine Research & Publications
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Browsing Veterinary Medicine Research & Publications by Department "Veterinary Clinical and Diagnostic Sciences"
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- ItemOpen AccessCarbon dioxide, but not isoflurane, elicits ultrasonic vocalisations in female rats(Sage Journals, 2013-10) Chisholm, J.; De Rantere, D.; Fernandez, N. J.; Krajacic, A.; Pang, Daniel S. J.
- ItemOpen AccessEffects of Prednisone on Blood Lactate Concentrations in Healthy Dogs(Wiley-Blackwell, 2009-07) Boysen, S. R.; Bozzetti, M.; Rose, L.; Dunn, M.; Pang, Daniel S. J.
- ItemOpen AccessThe effects of two dosages of midazolam on short-duration anesthesia in the juvenile Harp seal (Phoca groenlandica)(American Association of Zoo Veterinarians, 2006) Pang, Daniel S. J.; Rondenay, Yves; Measures, Lena; Lair, Stéphane
- ItemOpen AccessEvaluation of suitable reference genes for gene expression studies in bronchoalveolar lavage cells from horses with inflammatory airway disease(BioMed Central, 2011-01-28) Beekman, Laura; Tohver, Triin; Dardari, Rkia; Leguillette, Renaud
- ItemOpen AccessHemodynamic Effects of an Intravenous Infusion of Medetomidine at Six Different Dose Regimens in Isoflurane-Anesthetized Dogs(MediMedia Animal Health, 2010) Kaartinen, Johanna M.; Pang, Daniel S. J.; Moreau, Maxim; Vainio, Outi M.; Beaudry, Francis; del Castillo, Jérôme R. E.; Lamont, Leigh A.; Cuvelliez, Sophie G.; Troncy, Eric
- ItemOpen AccessIncreased Alveolar and Plasma Gelatinases Activity during Postpump Syndrome: Inhibition by Inhaled Nitric Oxide(Wolters Kluwer, 2006) Hubert, Bernard; Troncy, Eric; Gauvin, Dominique; Taha, Rame; Pang, Daniel S. J.; Beauchamp, Guy; Radomski, Anna; Radomski, Marek W.; Blaise, Gilbert A.
- ItemOpen AccessLactate in Veterinary Critical Care: Pathophysiology and Management(American Animal Hospital Association, 2007) Pang, Daniel S. J.; Boysen, Søren
- ItemOpen AccessPartial pressure of end-tidal CO2 sampled via an intranasal catheter as a substitute for partial pressure of arterial CO2 in dogs(Wiley-Blackwell, 2007-06) Pang, Daniel S. J.; Hethey, J.; Caulkett, N. A.; Duke, T.
- ItemOpen AccessRefinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (Rattus norvegicus)(BioMed Central, 2017-02-21) Zatroch, Katie K; Knight, Cameron G; Reimer, Julie N; Pang, Daniel S JBACKGROUND: The Canadian Council on Animal Care and American Veterinary Medical Association classify intraperitoneal (IP) pentobarbital as an acceptable euthanasia method in rats. However, national guidelines do not exist for a recommended dose or volume and IP euthanasia has been described as unreliable, with misinjections leading to variable success in ensuring a timely death. The aims of this study were to assess and improve efficacy and consistency of IP euthanasia. In a randomized, blinded study, 51 adult female Sprague-Dawley rats (170-495 g) received one of four treatments: low-dose low-volume (LL) IP pentobarbital (n = 13, 200 mg/kg pentobarbital), low-dose high-volume (LH) IP pentobarbital (n = 14, 200 mg/kg diluted 1:3 with phosphate buffered saline), high-dose high-volume (HH, n = 14, 800 mg/kg pentobarbital), or saline. Times to loss of righting reflex (LORR) and cessation of heartbeat (CHB) were recorded. To identify misinjections, necropsy examinations were performed on all rats. Video recordings of LL and HH groups were analyzed for pain-associated behaviors. Between-group comparisons were performed with 1-way ANOVA and Games-Howell post hoc tests. Variability in CHB was assessed by calculating the coefficient of variation (CV). RESULTS: The fastest euthanasia method (CHB) was HH (283.7 ± 38.0 s), compared with LL (485.8 ± 140.7 s, p = 0.002) and LH (347.7 ± 72.0 s, p = 0.039). Values for CV were: HH, 13.4%; LH, 20.7%; LL, 29.0%. LORR time was longest in LL (139.5 ± 29.6 s), compared with HH (111.6 ± 19.7 s, p = 0.046) and LH (104.2 ± 19.3 s, p = 0.01). Misinjections occurred in 17.0% (7/41) of euthanasia attempts. Pain-associated behavior incidence ranged from 36% (4/11, LL) to 46% (5/11, HH). CONCLUSIONS: These data illustrate refinement of the IP pentobarbital euthanasia technique. Both dose and volume contribute to speed of death, with a dose of 800 mg/kg (HH) being the most effective method. An increase in volume alone does not significantly reduce variability. The proportion of misinjections was similar to that of previous studies.
- ItemOpen AccessStudent Attainment of Proficiency in a Clinical Skill: The Assessment of Individual Learning Curves(Public Library of Science, 2014-02-20) Campbell, Robert D.; Hecker, Kent G.; Biau, David J.; Pang, Daniel S. J.
- ItemOpen AccessStudent Attainment of Proficiency in a Clinical Skill: The Assessment of Individual Learning Curves(Public Library of Science, 2014-02-20) Campbell, Robert D.; Hecker, Kent G.; Biau, David J.; Pang, Daniel S. J.
- ItemOpen AccessSuccessful treatment of hyperkalaemic periodic paralysis in a horse during isoflurane anaesthesia(Wiley-Blackwell, 2011-03) Pang, Daniel S. J.; Panizzi, Luca; Paterson, Jessica M.
- ItemOpen AccessSudden cardiac death associated with occult hypertrophic cardiomyopathy in a dog under anesthesia(Canadian Veterinary Medical Association, 2005) Pang, Daniel S. J.; Rondenay, Yves; Hélie, Pierre; Cuvelliez, Sophie G.; Troncy, Eric
- ItemOpen AccessSuitability of lingual venous blood to determine the acid-base and blood gas status of dogs under anesthesia(Wiley-Blackwell, 2009) Pang, Daniel S. J.; Allaire, Joakim; Rondenay, Yves; Kaartinen, Johanna; Cuvelliez, Sophie G.; Troncy, Eric
- ItemOpen AccessTarget-controlled infusion of propofol in dogs – evaluation of four targets for induction of anaesthesia(BMJ Publishing Group, 2005) Musk, Gabrielle C.; Pang, Daniel S. J.; Beths, Thierry; Flaherty, Derek A.