Schulich School of Engineering

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With an annual average of 25 internationally recognized research chairs, more than 160 faculty members and 1,200 graduate students, the Schulich School of Engineering at the University of Calgary is a powerhouse of research and innovation.

Schulich School of Engineering

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Browsing Schulich School of Engineering by Department "Other"

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    The influence of maximal and submaximal cyclic concentric and eccentric exercise on chondrocyte death and synovial fluid proteins in the rabbit knee
    (Elsevier, 2020-08) Abughazaleh, Nada; Abusara, Ziad; Krawetz, Roman J.; Herzog, Walter
    Mechanical stimulation of joints regulates the biosynthetic activity of chondrocytes. It has been argued that excessive loading might cause chondrocyte death, leading to degeneration of cartilage and cause osteoarthritis. The aims of this study were to apply a high, short-term loading, and a low intensity, long-term loading protocol to intact joints in life animals and determine changes in synovial fluid and the percentage of dead cells in rabbit knee cartilage
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    A statistical shape model of the tibia-fibula complex: sexual dimorphism and effects of age on reconstruction accuracy from anatomical landmarks
    (2021-11-03) Bruce, Olivia L; Baggaley, Michael; Welte, Lauren; Rainbow, Michael J; Edwards, W Brent
    A statistical shape model was created for a young adult population and used to predict tibia and fibula geometries from bony landmarks. Reconstruction errors with respect to CT data were quantified and compared to isometric scaling. Shape differences existed between sexes. The statistical shape model estimated tibia-fibula geometries from landmarks with high accuracy (RMSE = 1.51-1.62 mm), improving upon isometric scaling (RMSE = 1.78 mm). Reconstruction errors increased when the model was applied to older adults (RMSE = 2.11-2.17 mm). Improvements in geometric accuracy with shape model reconstruction changed hamstring moment arms 25-35% (1.0-1.3 mm) in young adults.
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    Tibial-fibular geometry and density variations associated with elevated bone strain and sex disparities in young active adults
    (Elsevier, 2022-05-20) Bruce, Olivia L; Baggaley, Michael; Khassetarash, Arash; Haider, Ifaz T; Edwards, W Brent
    Tibial stress fracture is a common injury in runners and military personnel. Elevated bone strain is believed to be associated with the development of stress fractures and is influenced by bone geometry and density. The purpose of this study was to characterize tibial-fibular geometry and density variations in young active adults, and to quantify the influence of these variations on finite element-predicted bone strain. A statistical appearance model characterising tibial-fibular geometry and density was developed from computed tomography scans of 48 young physically active adults. The model was perturbed ±1 and 2 standard deviations along each of the first five principal components to create finite element models. Average male and female finite element models, controlled for scale, were also generated. Muscle and joint forces in running, calculated using inverse dynamics-based static optimization, were applied to the finite element models. The resulting 95th percentile pressure-modified von Mises strain (peak strain) and strained volume (volume of elements above 4000 με) were quantified. Geometry and density variations described by principal components resulted in up to 12.0% differences in peak strain and 95.4% differences in strained volume when compared to the average tibia-fibula model. The average female illustrated 5.5% and 41.3% larger peak strain and strained volume, respectively, when compared to the average male, suggesting that sexual dimorphism in bone geometry may indeed contribute to greater stress fracture risk in females. Our findings identified important features in subject-specific geometry and density associated with elevated bone strain that may have implications for stress fracture risk.