• Information Technology
  • Human Resources
  • Careers
  • Giving
  • Library
  • Bookstore
  • Active Living
  • Continuing Education
  • Go Dinos
  • UCalgary Maps
  • UCalgary Directory
  • Academic Calendar
My UCalgary
Webmail
D2L
ARCHIBUS
IRISS
  • Faculty of Arts
  • Cumming School of Medicine
  • Faculty of Environmental Design
  • Faculty of Graduate Studies
  • Haskayne School of Business
  • Faculty of Kinesiology
  • Faculty of Law
  • Faculty of Nursing
  • Faculty of Nursing (Qatar)
  • Schulich School of Engineering
  • Faculty of Science
  • Faculty of Social Work
  • Faculty of Veterinary Medicine
  • Werklund School of Education
  • Information TechnologiesIT
  • Human ResourcesHR
  • Careers
  • Giving
  • Library
  • Bookstore
  • Active Living
  • Continuing Education
  • Go Dinos
  • UCalgary Maps
  • UCalgary Directory
  • Academic Calendar
  • Libraries and Cultural Resources
View Item 
  •   PRISM Home
  • Graduate Studies
  • The Vault: Electronic Theses and Dissertations
  • View Item
  •   PRISM Home
  • Graduate Studies
  • The Vault: Electronic Theses and Dissertations
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Investigating the Functional Role of Aquaporin 3 in Intestinal Epithelial Cells

Thumbnail
Download
Complete thesis (10.46Mb)
Advisor
MacNaughton, Wallace
Author
Morgan, Elizabeth Ellen
Committee Member
McKay, Derek
Beck, Paul
von der Weid, Pierre-Yves
Other
Aquaporin
Inflammatory bowel disease
Gastrointestinal
Subject
Biology--Cell
Biology--Molecular
Type
Thesis
Metadata
Show full item record

Abstract
Water is the most abundant molecule in human cells and biological systems, and aquaporin (AQP) proteins have an important role in facilitating transepithelial transport of water. Aquaporin 3 (AQP3) is an aquaglyceroporin that is permeable to water and small solutes, and is expressed in intestinal epithelial cells. Inflammatory bowel diseases are associated with barrier dysfunction and altered absorption and secretion. Given that AQPs are involved in these processes, and are decreased in IBD, we sought to better understand the importance of AQP3 in epithelial cells of the gastrointestinal tract. Our studies show that in the absence of AQP3, HT29 adenocarcinoma cells exhibit impaired growth which is due to decreased proliferation caused by an arrest in G2/M phase of the cell cycle, and not increased rates of cell death. These results improve the understanding of the functional role and importance of AQP3 in intestinal epithelial cell homeostasis.
Corporate
University of Calgary
Faculty
Graduate Studies
Doi
http://dx.doi.org/10.11575/PRISM/26641
Uri
http://hdl.handle.net/11023/3118
Collections
  • The Vault: Electronic Theses and Dissertations

Browse

All of PRISMCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

  • Email
  • SMS
  • 403.220.8895
  • Live Chat

Energize: The Campaign for Eyes High

Privacy Policy
Website feedback

University of Calgary
2500 University Drive NW
Calgary, AB T2N 1N4
CANADA

Copyright © 2017