The purpose of this quantitative study was to explore the relationship between amputation-related stressors, demographic variables and dyadic adjustment using a correlational study design. A convenience sample of 26 couples, in which one spouse had at least one amputation, were recruited over a four month period from three community-based sites in Calgary, Alberta. The majority of the amputees were male, prosthesis users, with nearly half of the overall sample involved in some kind of sports-related activities. Findings revealed that anxiety (p<0.01) was significantly negatively correlated with the amputee’s dyadic adjustment. For spouses, amputee depression (p<0.05) and pain-related interference (p<0.05) were negatively correlated with their dyadic adjustment, whereas the amputee’s adaptation to disability (p<0.05) was positively associated with dyadic adjustment. Age of spouse (p<0.05) and length of relationship (p<0.05) were positively related to dyadic adjustment in amputees. It is concluded that amputation-related stressors negatively correlate with the perception of dyadic adjustment; however the significance of stressors is perceived differently in amputees and spouses.