P. aeruginosa intra-species interactions and the role of pyocins in cystic fibrosis lung infections
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AbstractP. aeruginsoa is one of the most frequently isolated microorganisms that infect the lungs of cystic fibrosis (CF) patients, yet traditional antibiotic therapies rarely eradicate this organism. In our lab, we have observed P. aeruginosa intra-species antagonistic interactions between isolates from these patients. In the current study we have shown that these interactions are similar in both D. melanogaster and the mucosal surface rat prostate infection models. We have focused on one CF isolate (14651) involved in these antagonistic interactions. Our work demonstrated that 14651 produced pyocins, which were able to kill a wide-range of P. aeruginosa CF isolates. Our data further suggested that 14651 produced a novel S-type pyocin suggesting that it may have a competitive advantage by controlling other isolates in the lungs. This study raised the possibility that pyocins may be an effective therapeutic able to target a wide range of the P. aeruginosa CF isolates.
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