Mitigating arsenic toxicity through dietary selenium and biofortified lentils
Date
2012
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Abstract
Arsenic (As) toxicity causes senous health problems in humans. Selenium (Se), an important micronutrient and antioxidant acts as an antagonist of arsenic (As). Selenium is seriously deficient in Southeast Asian soils, but has good levels in Saskatchewan (SK) soils. We evaluated two kinds of Se manipulated diets in counteracting As toxicity in rats evident through liver damage (peroxidative stress), immunotoxicity (antibody response), depleted glutathione levels, as well as increased As residues in tissue (liver, kidney, whole blood) and excreta (urine, feces). For both studies, higher Se diets (rodent chow and lentil-based feed) resulted in higher glutathione (GSH), lower lipid peroxidative damage, recovered antibody response, higher fecal As excretion and lower renal As residues. These findings support the hypothesis that As toxicity is decreased through naturally high Se lentil diets as well as Se fortified rodent chow by reducing the As induced damage and eliminating As from the body.
Description
Bibliography: p. 116-144
A few pages are in colour.
Includes copy of animal protocol approval and copyright permission. Original copies with original Partial Copyright Licence.
A few pages are in colour.
Includes copy of animal protocol approval and copyright permission. Original copies with original Partial Copyright Licence.
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Citation
Sah, S. (2012). Mitigating arsenic toxicity through dietary selenium and biofortified lentils (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/5028