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dc.contributor.advisorGreen, Francis
dc.contributor.authorKoetzler, Rommy
dc.date.accessioned2005-08-08T20:05:20Z
dc.date.available2005-08-08T20:05:20Z
dc.date.issued2003
dc.identifier.citationKoetzler, R. (2003). Surfactant and bronchial response (Unpublished master's thesis). University of Calgary, Calgary, AB. doi:10.11575/PRISM/16378en_US
dc.identifier.isbn0612873099en
dc.identifier.urihttp://hdl.handle.net/1880/40090
dc.descriptionBibliography: p. 122-132en
dc.description.abstractA variety of clinical and experimental evidence indicates that surfactant may be important in the pathogenesis and treatment of asthma. The purpose of this study was to determine the effect of pulmonary surfactant and/or its components on precontracted rat bronchi. Left and right first generation bronchial tissues from male Sprague-Dawley rats were used in the studies done in vitro. Precontracted tissues were exposed to three kinds of surfactant: natural rat surfactant (NRS), bovine lipid extract surfactant (BLES), and Survanta. Surfactant was shown to relax rat bronchi in a concentration-dependent manner. The mechanism of surfactant-induced relaxation was determined. The surfactant relaxation response was inhibited when tissues were devoid of epithelium or when they were treated with indomethacin. N-co-nitro-L-arginine methyl ester (L-NAME) did not affect the surfactant-induced relaxation. Surfactant lipids, unsaturated phosphatidyicholine (uPC), dipalmitoylphosphatidylcholine (DPPC), and phosphatidyiglycerol (PG), and surfactant-specific protein A (SP-A) also showed a relaxant effect whereas non-surfactant lipids and proteins did not. We conclude that surfactant is an airway smooth muscle relaxant. The effect is specific and is dependent on the presence of epithelium and release of prostanoids, but is not dependent on the nitric oxide (NO) pathway.
dc.format.extentxvi, 139 leaves : ill. ; 30 cm.en
dc.language.isoeng
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleSurfactant and bronchial response
dc.typemaster thesis
dc.publisher.institutionUniversity of Calgaryen
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/16378
thesis.degree.nameMaster of Science (MSc)
thesis.degree.disciplineCardiovascular & Respiratory Sciences
thesis.degree.grantorUniversity of Calgary
dc.identifier.lccAC1 .T484 2003 K64en
dc.publisher.placeCalgaryen
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 1450 520708885


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University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.