Correlating Obstructive Symptoms with Stricture Severity in Ileal Crohn’s Disease

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dc.contributor.advisorLu, Cathy
dc.contributor.advisorBonni, Shirin
dc.contributor.authorSaunders, Bethany
dc.contributor.committeememberNovak, Kerri
dc.contributor.committeememberMa, Christopher
dc.contributor.committeememberGanesh, Aravind
dc.date2025-06-25
dc.date.accessioned2025-01-17T22:58:18Z
dc.date.available2025-01-17T22:58:18Z
dc.date.issued2024-11-28
dc.description.abstractCrohn’s Disease (CD) can manifest as inflammatory (non-stricturing), fibrostenotic (stricturing) and fistulizing or penetrating phenotypes. Stricturing CD, the main focus of this thesis, involves luminal narrowing and, which is often progressive leading to obstruction of the affected bowel segment. Obstructive symptoms (OS) in CD strictures can be assessed using the Stricture Definition and Treatment (STRIDENT) trial-used OS scoring system and CREOLE OS score. Clinically, OS are typically linked to advanced strictures, strictures can often result in dietary restrictions and surgery. No studies have been published to date, evaluating the severity of CD strictures and OS. Understanding the correlation between symptoms and strictures is crucial as regulatory bodies assess drug efficacy based on symptom response in CD trials. Intestinal ultrasound (IUS) accurately evaluates strictures morphology, with stricture severity and length, using established criteria: bowel wall thickness > 3mm, luminal narrowing (<1cm), with any pre-stenotic dilation (PSD) size (cm). The aim of this thesis based stsudy aims to determine if the OS of pain, bloating, nausea and/ or vomiting when comparing among CD phenotypes, and if specific OS correlate with any of the definitive stricture parameters.
dc.identifier.citationSaunders, B. (2025). Correlating obstructive symptoms with stricture severity in ileal Crohn’s disease (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/120477
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectCrohns Disease
dc.subjectMedicine
dc.subjectStrictures
dc.subjectBowel Obstruction
dc.subjectSurgery
dc.subjectSymptoms
dc.subjectObstructive Symptoms
dc.subject.classificationMedicine and Surgery
dc.titleCorrelating Obstructive Symptoms with Stricture Severity in Ileal Crohn’s Disease
dc.typemaster thesis
thesis.degree.disciplineMedicine – Medical Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.thesis.accesssetbystudentI require a thesis withhold – I need to delay the release of my thesis due to a patent application, and other reasons outlined in the link above. I have/will need to submit a thesis withhold application.
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