Using finite element models under multiple loading conditions to improve the association between radius and tibia microarchitecture and prevalent osteoporotic vertebral fracture

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dc.contributor.advisorBoyd, Steven Kyle
dc.contributor.authorGeorge, Jacob Koshy
dc.contributor.committeememberKuo, Arthur D.
dc.contributor.committeememberDuncan, Neil A.
dc.date2018-11
dc.date.accessioned2018-06-08T20:44:56Z
dc.date.available2018-06-08T20:44:56Z
dc.date.issued2018-05-31
dc.description.abstractBone microarchitecture differences at the tibia and radius, measurable by high-resolution peripheral quantitative computed tomography (HR-pQCT) exist between individuals with a prevalent vertebral fracture and healthy controls. As fracture is a result of mechanical failure, FE models of these sites in physiologically relevant loading conditions (compression, torsion, bending) may reveal insight into fracture pathogenesis uncaptured by microarchitecture. In this study, HR-pQCT scans at the tibia and radius were collected from post-menopausal women with prevalent vertebral fracture and healthy controls, from which microarchitecture and finite element outcomes (Pistoia failure load, apparent modulus) were calculated. At the tibia, a one standard deviation increase in compressive failure load was most strongly associated with fracture risk reduction (OR= 0.369, p=0.002), followed by compressive apparent modulus (OR= 0.473, p=0.010), torsion apparent modulus (OR= 0.493, p=0.023), and bending apparent modulus (OR=0.550, p=0.010). At the radius, failure load was the only FE outcome associated with fracture risk reduction (OR=0.534, p=0.023). None of the FE outcomes improved fracture discrimination compared to measures of bone microarchitecture. This study demonstrates the applicability of using FE under multiple loading conditions to evaluate bone structure changes related to osteoporotic fracture.en_US
dc.identifier.citationGeorge, J. K. (2018). Using finite element models under multiple loading conditions to improve the association between radius and tibia microarchitecture and prevalent osteoporotic vertebral fracture (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/31976en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/31976
dc.identifier.urihttp://hdl.handle.net/1880/106748
dc.language.isoeng
dc.publisher.facultyCumming School of Medicine
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectFinite Element Analysis
dc.subjectHR-pQCT
dc.subjectfracture
dc.subjectbone microarchitecture
dc.subject.classificationRadiologyen_US
dc.subject.classificationEngineering--Biomedicalen_US
dc.subject.classificationEngineering--Mechanicalen_US
dc.titleUsing finite element models under multiple loading conditions to improve the association between radius and tibia microarchitecture and prevalent osteoporotic vertebral fracture
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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