Elucidating the Relationship Between Macrophages and Synovial Mesenchymal Progenitor Cell Chondrogenesis

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atmire.migration.oldid2682
dc.contributor.advisorKrawetz, Roman
dc.contributor.authorFichadiya, Akash
dc.date.accessioned2014-10-02T14:59:39Z
dc.date.available2014-11-17T08:00:51Z
dc.date.issued2014-10-02
dc.date.submitted2014en
dc.description.abstractOsteoarthritis (OA) is a complex disease affecting articular cartilage and joint tissues. Macrophages in OA synovium contribute to the inflamed joint environment by releasing inflammatory mediators promoting cartilage loss. What remains unknown is how macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs are able to differentiate into cartilage but for unknown reasons, sMPC chondrogenic capacity is lost in OA. This thesis elucidates the relationship between macrophages and sMPC using synovial explants obtained from OA and normal patients. I found that altered macrophage activity (through cytokine stimulation and/or macrophage depletion) differentially regulates the chondrogenic capacity of sMPCs in a patient-specific manner. Also, the secretory profile of the explant is different between normal and OA patients in response to treatment. Taken together, there is heterogeneity within the responses of the OA patients, highlighting the need for personalized approaches to repair the cartilage within the OA joint.en_US
dc.identifier.citationFichadiya, A. (2014). Elucidating the Relationship Between Macrophages and Synovial Mesenchymal Progenitor Cell Chondrogenesis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25868en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25868
dc.identifier.urihttp://hdl.handle.net/11023/1904
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subjectBiology--Molecular
dc.subject.classificationMesenchymalen_US
dc.subject.classificationSTEMen_US
dc.subject.classificationmacrophageen_US
dc.subject.classificationOsteoarthritisen_US
dc.titleElucidating the Relationship Between Macrophages and Synovial Mesenchymal Progenitor Cell Chondrogenesis
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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