Neurobiological Substrates of Age-Associated Decline in Neuronal Excitability - Lipid Peroxidation-Dependent Modulation of Transient Potassium Current Inactivation?

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atmire.migration.oldid606
dc.contributor.advisorWildering, Wic
dc.contributor.authorNelson, Mark A.
dc.date.accessioned2013-01-21T20:40:24Z
dc.date.available2013-06-15T07:01:45Z
dc.date.issued2013-01-21
dc.date.submitted2013en
dc.description.abstractAging is a universal phenomenon that is observed in almost all organisms within the animal kingdom, yet the biological substrates that underlie the onset and progression of aging are not entirely understood. While aging produces dysfunction in all organ systems, aging of the nervous system can result in severe consequences including age-associated cognitive impairment and deficiencies in learning and memory formation. Long term memory formation often involves repetitive, high frequency periods activity and therefore is affected by electrophysiological properties of the nervous system, including neuronal excitability: excitability of the nervous system declines with age and this may contribute to age-associated cognitive dysfunction. This thesis will investigate age-associated intrinsic neuronal excitability decline in the model system Lymnaea stagnalis, investigate the ionic mechanisms underlying this dysfunction with a focus on voltage gated potassium channels, and seek to implicate oxidative stress and lipid peroxidation with the aging process in these neurons.en_US
dc.identifier.citationNelson, M. A. (2013). Neurobiological Substrates of Age-Associated Decline in Neuronal Excitability - Lipid Peroxidation-Dependent Modulation of Transient Potassium Current Inactivation? (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27081en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27081
dc.identifier.urihttp://hdl.handle.net/11023/440
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectNeuroscience
dc.subjectZoology
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationAgingen_US
dc.subject.classificationLymnaea stagnalisen_US
dc.subject.classificationExcitabilityen_US
dc.subject.classificationVoltage-gated potassium currentsen_US
dc.subject.classificationFrequency-dependent spike broadeningen_US
dc.subject.classificationLearning and memoryen_US
dc.subject.classificationSenescenceen_US
dc.subject.classificationLipid peroxidationen_US
dc.subject.classificationVitamin Een_US
dc.titleNeurobiological Substrates of Age-Associated Decline in Neuronal Excitability - Lipid Peroxidation-Dependent Modulation of Transient Potassium Current Inactivation?
dc.typemaster thesis
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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