Motor Network Organization in Frontal Lobe Epilepsy

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atmire.migration.oldid1034
dc.contributor.advisorFederico, Paolo
dc.contributor.authorWoodward, Kristine
dc.date.accessioned2013-05-31T16:09:39Z
dc.date.available2013-11-12T08:00:12Z
dc.date.embargolift2200-01-01T00:00:01Z
dc.date.issued2013-05-31
dc.date.submitted2013en
dc.description.abstractFrontal lobe epilepsy (FLE) is a seizure disorder that commonly coincides with functional motor deficits. While the source of these deficits is unknown, it is postulated that repeated seizure activity within the frontal lobe might impact the proximate motor network. To examine this hypothesis, motor networks were compared between participants with right FLE, left FLE, and controls using two methods. The first was a task-based fMRI study of brain activation during simple and complex motor tasks, and the second was a resting-state fMRI study of motor network connectivity. Both studies revealed motor network disturbances in participants with FLE, disturbances that were more pronounced in participants with higher seizure burden factors. These results show that motor networks are altered in FLE. In the future, motor fMRI studies may help identify the locations of seizure foci, predict post-surgical motor deficits, and ultimately improve the quality of life of patients with FLE.en_US
dc.identifier.citationWoodward, K. (2013). Motor Network Organization in Frontal Lobe Epilepsy (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27016en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27016
dc.identifier.urihttp://hdl.handle.net/11023/747
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectRadiology
dc.subject.classificationEpilepsyen_US
dc.titleMotor Network Organization in Frontal Lobe Epilepsy
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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