Observations in Lipid Membrane Systems

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atmire.migration.oldid3604
dc.contributor.advisorAmrein, Matthias
dc.contributor.advisorShi, Yan
dc.contributor.authorMunro, Fay
dc.date.accessioned2015-09-18T21:07:08Z
dc.date.available2015-11-20T08:00:40Z
dc.date.issued2015-09-18
dc.date.submitted2015en
dc.description.abstractThe plasma membrane is phase separated into a fluid (Ld) phase and a more ordered (Lo) phase. The latter exists as small “rafts” of specific lipid composition containing a host of signaling proteins. Lipid raft theory links the aggregation of rafts to a signaling event. In its current iteration, the theory is incomplete, as it does not explain how rafts form and how they aggregate and disperse again. These problems are addressed when the membrane is viewed as a critical system. Previous work using giant plasma membrane vesicles (GPMVs) used this framework to explain the dynamics of the rafts. We intended to show critical behavior as a factor for cell signaling. Critical behavior was not easily ascertained and further observations were made. We found a heterogeneous population with respect to the behavior of the vesicles. We categorized these observations with respect to the appearance of the lipid membrane to characterize the phenomenon.en_US
dc.identifier.citationMunro, F. (2015). Observations in Lipid Membrane Systems (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27158en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27158
dc.identifier.urihttp://hdl.handle.net/11023/2468
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subject.classificationLipidsen_US
dc.subject.classificationMembraneen_US
dc.subject.classificationSignalingen_US
dc.titleObservations in Lipid Membrane Systems
dc.typemaster thesis
thesis.degree.disciplineCardiovascular & Respiratory Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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