Predictors of Response to Repetitive Transcranial Magnetic Stimulation Treatment in Adolescent Major Depressive Disorder

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dc.contributor.advisorMacMaster, Frank P.
dc.contributor.authorMcLellan, Quinn Kenneth
dc.contributor.committeememberArnold, Paul Daniel
dc.contributor.committeememberBulloch, Andrew G. M.
dc.date2018-06
dc.date.accessioned2018-04-30T17:48:58Z
dc.date.available2018-04-30T17:48:58Z
dc.date.issued2018-04-27
dc.description.abstractAdolescent major depressive disorder has limited treatment options and response is unpredictable. Repetitive transcranial magnetic stimulation (rTMS) is a novel treatment option while pre-treatment cortical thickness may be an objective biomarker predictive of response. Twenty-three youth (12-21 years; 11 female) with treatment-resistant depression (TRD) underwent 3 weeks of high-frequency rTMS. Baseline left rostral middle frontal gyrus (lRMF) thickness was compared between eventual responders, non-responders and age-matched controls (n=16; 10 female). Symptom-specific treatment response, defined as ≥50% symptom reduction, was evaluated. Demographic and symptom profile differences were explored. Interventional rTMS alleviated both anxious and depressive symptoms. lRMF was thinner in responders than non-responders, and age negatively correlated with lRMF thickness in controls but not TRD subjects. Exploration of demographic and symptom variables showed responders on the depressive measure had greater frequency of past suicide attempts and higher atypical symptom cluster score while social phobia was associated with non-responsiveness.en_US
dc.identifier.citationMcLellan, Q. K. (2018). Predictors of Response to Repetitive Transcranial Magnetic Stimulation Treatment in Adolescent Major Depressive Disorder (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/31859en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/31859
dc.identifier.urihttp://hdl.handle.net/1880/106573
dc.language.isoeng
dc.publisher.facultyCumming School of Medicine
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectadolescent
dc.subjectMajor depressive disorder
dc.subjectrepetitive transcranial magnetic stimulation
dc.subjectneuroimaging
dc.subjectbiomarkers
dc.subjectpredictors of response
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationPsychology--Clinicalen_US
dc.titlePredictors of Response to Repetitive Transcranial Magnetic Stimulation Treatment in Adolescent Major Depressive Disorder
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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