Cortical Excitability after Mild Traumatic Brain Injury in Children

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atmire.migration.oldid3890
dc.contributor.advisorBarlow, Karen
dc.contributor.advisorKirton, Adam
dc.contributor.authorSeeger, Trevor
dc.contributor.committeememberDunn, Jeff
dc.contributor.committeememberGallagher, Clare
dc.contributor.committeememberEsser, Michael
dc.date.accessioned2015-12-04T20:03:07Z
dc.date.available2015-12-04T20:03:07Z
dc.date.issued2015-12-04
dc.date.submitted2015en
dc.description.abstractIntroduction: Mild traumatic brain injury is frequently complicated by post-concussive syndrome. It is unknown why these symptoms persist, but recent research suggests that cortical excitability may play a role. Objectives: To determine if cortical excitability is different in pediatric mTBI, and if it correlates with symptom persistence. Methods:This was a cross-sectional controlled cohort study. Cortical excitability was measured using a variety of TMS paradigms in children with (symptomatic) and without (asymptomatic) persistent symptoms at one month post injury. The primary outcome measure was the corticalsilent period (cSP) (thought to represent GABAergic inhibition). Results: 57 children with mTBI (44% male; age 14.23 (SD:2.49)) and 28 controls were compared. cSP was similar between groups (F(2, 70)=0.53, p=0.591). There were no other significant group differences in cortical excitability. Conclusions: TMS was well tolerated in children with mTBI. Cortical excitability is similar to normal children at one-month following the injury.en_US
dc.identifier.citationSeeger, T. (2015). Cortical Excitability after Mild Traumatic Brain Injury in Children (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25470en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25470
dc.identifier.urihttp://hdl.handle.net/11023/2659
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationTraumatic Brain Injuryen_US
dc.subject.classificationConcussionen_US
dc.subject.classificationmild traumatic brain injuryen_US
dc.subject.classificationTranscranial Magnetic Stimulationen_US
dc.subject.classificationCortical Silent Perioden_US
dc.subject.classificationPaediatricsen_US
dc.titleCortical Excitability after Mild Traumatic Brain Injury in Children
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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