Keratoconjunctival effects of diabetes mellitus in dogs

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dc.contributor.authorCullen, Cheryl Leng
dc.contributor.authorIhle, Sherri Leng
dc.contributor.authorWebb, Aubrey Aeng
dc.contributor.authorMcCarville, Caroleng
dc.date.accessioned2008-08-20T20:54:38Z
dc.date.available2008-08-20T20:54:38Z
dc.date.issued2005-07
dc.description.abstractObjectives: To compare Schirmer tear test (STT)values, corneal sensitivity, tear film break up times (TFBUTs), and tear glucose concentrations in relation to conjunctival microflora, and conjunctival cytologic and histologic findings among diabetic cataractous, nondiabetic cataractous, and nondiabetic noncataractous dogs. Procedures: Fifteen dogs in each category underwent neuro-ophthalmic examination; aerobic and fungal conjunctival cultures; assessment of corneal touch threshold (CTT), STT, tear glucose, TFBUT; and conjunctival cytology ahd histology (in certain cases only). Degree of cataract and uveitis were critically graded. Glycemic control was estimated using serum fructosamine and glycosylated hemoglobin. Results: STT values were significantly lower in diabetic cataractous than nondiabetic noncataractous dogs. CTT of diabetic cataractous dogs was significantly lower than that of nondiabetic noncataractous dogs. Mean TFBUTs were significantly less in diabetic cataractous dogs than nondiabetic cataractous and nondiabetic noncataractous dogs. Tear glucose concentratons were significantly higher in diabetic cataractous dogs than nondiabetic cataractous and nondiabetic noncataractous dogs. Conjunctival microbial isolates did not differ among groups. There were no significant differences in degree of cataract or uveitis between diabetic cataractous and nondiabetic cataractous groups. There was mild submucosal inflammatory infiltrate in conjunctival speciments from diabetic dogs. Conjunctival epithelial dysplasia and/or squamous metaplasia was/were detected in conjunctival biopsies of 5/7 diabetic dogs. Reductions in conjuctival goblet cell (GC) densities were noted in 4/7 diabetic dogs; there were no significant differences in mean GC densities among the three groups. Conclusions: Diabtic cataractous dogs have significantly altered keratoconjunctival characteristics compared to nondiabetic cataractous and nondiabetic noncataractous dogs.eng
dc.description.notesThe definitive version is available at www3.interscience.wiley.com
dc.description.refereedYeseng
dc.identifier.citationVeterinary Ophthalmology (2005) 8(4), 215-224eng
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35625
dc.identifier.issn1463-5216
dc.identifier.urihttp://hdl.handle.net/1880/46762
dc.language.isoengeng
dc.publisherBlackwelleng
dc.publisher.corporateUniversity of Calgaryeng
dc.publisher.facultyVeterinary Medicineeng
dc.publisher.urlhttp://www3.interscience.wiley.com.ezproxy.lib.ucalgary.ca/journal/118507707/homeeng
dc.subjectdogseng
dc.subject.otherconjunctival microfloraeng
dc.subject.othercorneal sensitivityeng
dc.titleKeratoconjunctival effects of diabetes mellitus in dogseng
dc.typejournal article
thesis.degree.disciplineComparative Biology and Experimental Medicineeng
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