The Gut Microbiome of Premature Infants: An Ecological Analysis of a Probiotic Intervention Study

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dc.contributor.advisorArrieta, Marie Claire
dc.contributor.advisorMcCoy, Kathy
dc.contributor.authorSamara, Jumana
dc.contributor.committeememberLacaze-Masmonteil, Thierry
dc.contributor.committeememberAlshaikh, Belal
dc.date2021-11
dc.date.accessioned2021-10-06T22:30:28Z
dc.date.available2021-10-06T22:30:28Z
dc.date.issued2021-10
dc.description.abstractPreterm infants are a unique population of patients, as prematurity is the leading cause of death in children under 5 years of age, and survivors are extremely challenged during their early and future life 1. Due to prematurity on every system, challenges faced by preterm infant early and later in life include, and are not limited to respiratory, digestive, immune, neurological, and growth-related conditions that can lead to life threatening complications and an increased risk to several diseases later in life 2-4. Probiotic strains are increasingly used in preterm infants due to their potential to reduce mortality and morbidities in this population. However, due to reduced evidence on safety and efficacy, these are not routinely used in extremely premature infants. The infant gut undergoes important developmental stages that are dependent upon the colonization with microorganism, beginning at birth 5. While it is well established that the premature gut microbiome exhibits profound alterations, the ecological patterns of microbial assembly and succession in preterm infants remained understudied and have only included bacteria. Moreover, it is not well understood how these processes are impacted by probiotics. The goal of my MSc research is to determine if probiotics use changes gut colonization patterns of the gut microbiome during and after treatment, and if the probiotic strains can persist in the gut of extremely premature infants. We showed a successful colonization of probiotics strains in the gut of extremely low birth weight preterm infants in addition to significant ecological changes of bacterial and fungal microbiome during the probiotic’s consumption and up to 6 months after treatment cessation. Our results confirmed that early life colonization with healthy bacteria beneficially impacts the future microbiome in extremely preterm infants.en_US
dc.identifier.citationSamara, J. (2021). The gut microbiome of premature infants: an ecological analysis of a probiotic intervention study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/39342
dc.identifier.urihttp://hdl.handle.net/1880/114035
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectProbioticsen_US
dc.subjectmicrobiomeen_US
dc.subjectdiversityen_US
dc.subjectpreterm infantsen_US
dc.subjectpremature infantsen_US
dc.subjectprematurityen_US
dc.subjectextreme low birth weighten_US
dc.subjectELBWen_US
dc.subjectNICUen_US
dc.subjectNeonatologyen_US
dc.subject.classificationEducation--Healthen_US
dc.subject.classificationMicrobiologyen_US
dc.subject.classificationImmunologyen_US
dc.subject.classificationMedicine and Surgeryen_US
dc.subject.classificationNutritionen_US
dc.titleThe Gut Microbiome of Premature Infants: An Ecological Analysis of a Probiotic Intervention Studyen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Microbiology & Infectious Diseasesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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