Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection

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atmire.migration.oldid4974
dc.contributor.advisorProud, David
dc.contributor.authorMinor, Danielle Marie
dc.contributor.committeememberGiembycz, Mark
dc.contributor.committeememberKelly, Margaret
dc.date.accessioned2016-09-27T22:09:49Z
dc.date.available2016-09-27T22:09:49Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractHuman rhinovirus (HRV)-induced wheezing illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR that is due to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused phenotypic changes in epithelial cells consistent with the process of epithelial to mesenchymal transition. Viral replication was not essential for phenotypic changes, which appear to be mediated, in part, via activation of mitogen activated protein kinase pathways, and via induction of the transcription factor, SLUG. These data support a role for HRV in the development and progression of AR.en_US
dc.identifier.citationMinor, D. M. (2016). Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25276en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25276
dc.identifier.urihttp://hdl.handle.net/11023/3332
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiophysics--Medical
dc.subject.classificationEpithelial cellsen_US
dc.subject.classificationHuman rhinovirusen_US
dc.subject.classificationepithelial to mesenchymal transitionen_US
dc.titleCharacterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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