Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change

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atmire.migration.oldid2388
dc.contributor.advisorSmith, Eric
dc.contributor.advisorGoodyear, Bradley
dc.contributor.authorSwitzer, Aaron
dc.date.accessioned2014-08-15T21:38:56Z
dc.date.available2014-11-17T08:00:42Z
dc.date.issued2014-08-15
dc.date.submitted2014en
dc.description.abstractCerebral amyloid angiopathy (CAA) refers to the deposition of Abeta (Aβ) peptides in the brains small blood vessels leading to hemorrhagic stroke and cognitive impairment. Aβ is toxic to smooth muscle cells and impairs blood flow regulation. Reduced blood oxygen level dependent (BOLD) signal amplitude in response to a visual fMRI task has recently been implicated as a surrogate marker for impaired vascular reactivity in CAA. There have been no studies investigating how the BOLD amplitude changes in other Aβ diseases that present with CAA (Alzheimer’s disease (AD) or mild cognitive impairment (MCI)), or how it changes over time in CAA. BOLD amplitudes were lowest in CAA compared to controls but were not lower in MCI or AD. BOLD amplitudes decreased over 1-year in CAA but not in controls. These results provide more evidence for the use of BOLD amplitudes as a measure of impaired vascular reactivity in CAA.en_US
dc.identifier.citationSwitzer, A. (2014). Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28634en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28634
dc.identifier.urihttp://hdl.handle.net/11023/1687
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationCerebral Amyloid Angiopathyen_US
dc.subject.classificationAlzheimer's Diseaseen_US
dc.subject.classificationFunctional MRIen_US
dc.subject.classificationBlood Oxygen Level Dependenten_US
dc.subject.classificationLongitudinalen_US
dc.titleVascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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