Neuro-Electronic Interface: Interrogating Neuronal Function and Circuitry with Innovative Approaches

Wijdenes, Pierre

Neuro-Electronic Interface: Interrogating Neuronal Function and Circuitry with Innovative Approaches

dc.contributor.advisor	Syed, Naweed
dc.contributor.author	Wijdenes, Pierre
dc.contributor.committeemember	Teskey, Cam
dc.contributor.committeemember	Dalton, Colin
dc.contributor.committeemember	Rho, Jong
dc.date	2018-06
dc.date.accessioned	2018-01-25T18:54:07Z
dc.date.available	2018-01-25T18:54:07Z
dc.date.issued	2018-01-22
dc.description.abstract	All nervous system functions, ranging from simple reflexes to complex behaviors and learning and memory, rely on networks of interconnected brain cells called neurons. Loss of various neuronal circuit functions, due either to stroke, epilepsy, trauma, Parkinson's, Alzheimer's or neurodegenerative diseases, renders the nervous system dysfunctional. Epilepsy alone is one of the most common and debilitating neurological disorder, which affects about 65 million people worldwide – representing 1% of the global population. Because natural replacement of injured or diseased nervous system tissue seldom, if ever, occurs, this loss of function is often irreversible and leaves patients incapacitated for life. The lack of fundamental knowledge in the field of neurological disorders, such as epilepsy, owes its existence to the intricacies of neuronal networks, and our inability to monitor their activities at the resolution of individual neurons. Thus, several laboratories in the world have developed brain-chip interface technologies that allow the interrogation of neuronal function non-invasively and over an extended time period. A variety of neuro-electronic interfaces now allow fundamental understanding of brain function, ranging from monitoring ion channel activities, to synaptic plasticity 4, and brain-controlled prosthetic devices. However, there are several limitations to the existing micro-electrode designs, their biocompatibility and resolution, when monitoring both normal and perturbed activity patterns, for example during epilepsy. Thus, the main objective of my thesis was to develop a set of novel micro-electrode arrays (MEAs) that could fill this technological gap, allowing for the detection, characterization, and modulation of neural activity from individual cells to neuronal networks.	en_US
dc.identifier.citation	Wijdenes P. (2018). Neuro-Electronic Interface: Interrogating Neuronal Function and Circuitry with Innovative Approaches (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/5407
dc.identifier.uri	http://hdl.handle.net/1880/106326
dc.language.iso	en	en_US
dc.publisher.faculty	Schulich School of Engineering	en_US
dc.publisher.institution	University of Calgary	en
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject.classification	Education--Sciences	en_US
dc.subject.classification	Education--Technology	en_US
dc.subject.classification	Biology--Cell	en_US
dc.subject.classification	Neuroscience	en_US
dc.subject.classification	Biophysics--Medical	en_US
dc.subject.classification	Rehabilitation and Therapy	en_US
dc.subject.classification	Engineering--Biomedical	en_US
dc.title	Neuro-Electronic Interface: Interrogating Neuronal Function and Circuitry with Innovative Approaches	en_US
dc.type	doctoral thesis	en_US
thesis.degree.discipline	Engineering – Biomedical	en_US
thesis.degree.grantor	University of Calgary	en_US
thesis.degree.name	Doctor of Philosophy (PhD)	en_US
ucalgary.item.requestcopy	true
ucalgary.thesis.checklist	I confirm that I have submitted all of the required forms to Faculty of Graduate Studies.	en_US