Alternating Current Stimulation for Essential Tremor

Simple item page
dc.contributor.advisorMartino, Davide
dc.contributor.advisorStrzalkowski, Nick
dc.contributor.authorAdeoti, Adesewa Janet
dc.contributor.committeememberDebert, Chantel
dc.contributor.committeememberPichardo, Sam
dc.contributor.committeememberAsmussen, Mike
dc.contributor.committeememberDickinson, James
dc.date2024-11
dc.date.accessioned2024-09-19T19:59:40Z
dc.date.available2024-09-19T19:59:40Z
dc.date.issued2024-09-18
dc.description.abstractEssential tremor is the most common movement disorder, characterized by involuntary rhythmic shaking of the hands, head, trunk, vocal cords, or legs. While the pathophysiological mechanisms of essential tremor are not fully understood, research suggests the involvement of a complex network called the cerebello-thalamo-cortical network. This network includes the inferior olive nuclei, cerebellum, red nucleus, thalamus, and cerebral cortex. Tremor generation in essential tremor is believed to be linked to neurodegeneration, abnormalities in a central oscillatory network, or dysfunction of the inhibitory neurotransmitter gamma-aminobutyric acid. Current treatments for essential tremor are largely unappealing to patients due to either being invasive (surgical), ineffective, and/or causing severe side effects. Previous studies on the impact of ACS in tremor are limited in number and lack a standardized protocol. The aim of this thesis was to investigate the effects of open-loop transcranial and transcutaneous alternating current stimulation on tremor in essential tremor, when delivered over the primary motor cortex and arm at a patient’s dominant tremor frequency. Our results revealed that both transcranial and transcutaneous open-loop alternating current stimulation, delivered to the primary motor cortex and upper arm at a patient’s dominant tremor frequency did not reduce tremor amplitude nor increase tremor ratio. Our study, being the first of its kind, informs on the need for more proof of principle studies in this field that will narrow down the most effective stimulation parameters, and structural targets.
dc.identifier.citationAdeoti, A. J. (2024). Alternating current stimulation for essential tremor (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/119820
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEssential Tremor
dc.subjectAlternating Current Stimulation
dc.subjectMovement Disorder
dc.subjectTremor
dc.subjectNon-invasive Neurostimulation
dc.subject.classificationNeuroscience
dc.subject.classificationBiophysics--Medical
dc.subject.classificationEducation--Sciences
dc.subject.classificationEducation--Health
dc.titleAlternating Current Stimulation for Essential Tremor
dc.typemaster thesis
thesis.degree.disciplineMedicine – Neuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2024_adeoti_adesewa.pdf
Size:
1.69 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations