The Role of Orexin in Modulating Locomotion

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atmire.migration.oldid4646
dc.contributor.advisorWhelan, Patrick
dc.contributor.authorBiswabharati, Sukanya
dc.contributor.committeememberBains, Jaideep
dc.contributor.committeememberBorgland, Stephanie
dc.contributor.committeememberWildering, Willem Carel
dc.date.accessioned2016-07-13T19:26:06Z
dc.date.available2016-07-13T19:26:06Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractThe neuropeptides, orexin A/ B, are produced in the lateral hypothalamic region of the brain and are widely released in the central nervous system including locomotor regions in the brainstem and the lumbar spinal cord. Multiple lines of evidence implicate orexin as being capable of influencing locomotion. However, the direct role of orexin in modulating locomotion is not known. Motor networks, which produce rhythmic patterns of activity for locomotion in the hindlimbs reside primarily in the lumbar spinal cord. My work addressed whether direct orexinergic modulation of spinal circuits can affect locomotor behavior. Data, obtained from neurogram recordings of isolated spinal cord preparations, show that application of orexin can powerfully affect the frequency of the locomotor rhythm. Additionally, experiments performed to delineate the effect of orexin onto isolated networks of the motoneurons showed a considerable increase in the firing rate of motoneurons, further suggesting orexin’s involvement in the locomotor circuitry.en_US
dc.identifier.citationBiswabharati, S. (2016). The Role of Orexin in Modulating Locomotion (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28341en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28341
dc.identifier.urihttp://hdl.handle.net/11023/3126
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationSpinal Corden_US
dc.subject.classificationorexinen_US
dc.subject.classificationlocomotionen_US
dc.titleThe Role of Orexin in Modulating Locomotion
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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