The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome

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atmire.migration.oldid2721
dc.contributor.advisorEsser, Michael
dc.contributor.authorFarran, Allyson
dc.date.accessioned2014-10-22T21:05:42Z
dc.date.available2015-02-23T08:00:28Z
dc.date.issued2014-10-22
dc.date.submitted2014en
dc.description.abstractApproximately 1.4 million people in the United States each year sustain a mild traumatic brain injury (mTBI). Unfortunately, approximately 15% of these patients will have post- concussive symptoms that last longer than three months. Knowledge of the pathophysiological processes underlying susceptibility to poor outcomes is limited, which has impaired the development of effective therapeutics for patients with a mTBI. The present study was designed to assess behavioral and molecular changes post-mTBI in an animal model of genetic susceptibility to poor neurological outcomes, the Kir6.2-knockout mouse. We conducted multiple behavioral tests and analyzed the cellular stress response through assessment of heat shock protein (Hsps) gene expression. We hypothesized that following mTBI, Kir6.2-knockout mice would have increased behavioral deficits, and aberrant Hsp expression. Results from behavioral and molecular analyses demonstrated that outcomes post-mTBI depended on sex and genetic make-up, and that the influence of these factors changed throughout the recovery process.en_US
dc.identifier.citationFarran, A. (2014). The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28226en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28226
dc.identifier.urihttp://hdl.handle.net/11023/1933
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationConcussionen_US
dc.subject.classificationSusceptibilityen_US
dc.subject.classificationHeat Shock Proteinen_US
dc.subject.classificationTraumatic Brain Injuryen_US
dc.titleThe KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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