Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook

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dc.contributor.authorNavis, Kathleen E
dc.contributor.authorFan, Churmy Y
dc.contributor.authorTrang, Tuan
dc.contributor.authorThompson, Roger J
dc.contributor.authorDerksen, Darren J
dc.date.accessioned2021-09-01T22:42:10Z
dc.date.available2021-09-01T22:42:10Z
dc.date.issued2020-01
dc.descriptionFunding for this research was provided through a Queen Elizabeth II Graduate Research Scholarship, Alberta Graduate Excellence Scholarship (AGES), Natural Sciences and Engineering Research Council (NSERC), CIHR (Canadian Institutes of Health Research), and the Alberta Children’s Hospital Foundation and Research Institute.en_US
dc.description.abstractPannexin 1 (Panx1) channels are transmembrane proteins that release adenosine triphosphate and play an important role in intercellular communication. They are widely expressed in somatic and nervous system tissues, and their activity has been associated with many pathologies such as stroke, epilepsy, inflammation, and chronic pain. While there are a variety of small molecules known to inhibit Panx1, currently little is known about the mechanism of channel inhibition, and there is a dearth of sufficiently potent and selective drugs targeting Panx1. Herein we provide a review of the current literature on Panx1 structural biology and known pharmacological agents that will help provide a basis for rational development of Panx1 chemical modulators.en_US
dc.identifier.citationNavis, K. E., Fan, C. Y., Trang, T., Thompson, R. J., & Derksen, D. J. (2020). Pannexin 1 channels as a therapeutic target: Structure, inhibition, and outlook. ACS Chemical Neuroscience, 11(15), 2163-2172.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/acschemneuro.0c00333en_US
dc.identifier.urihttp://hdl.handle.net/1880/113803
dc.language.isoengen_US
dc.publisher.departmentChemistryen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.facultyScienceen_US
dc.publisher.hasversionacceptedVersionen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectPannexin 1en_US
dc.subjectPharmacologyen_US
dc.subjectInhibitionen_US
dc.subjectMedicinal Chemistryen_US
dc.subjectChannelen_US
dc.subjectStructureen_US
dc.titlePannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlooken_US
dc.typejournal articleen_US
ucalgary.item.requestcopytrueen_US
ucalgary.scholar.levelFacultyen_US
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