Lymphatic vessel function in a guinea pig model of intestinal inflammation, and the role of inflammatory mediators

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dc.contributor.advisorvon der Weid, Pierre-Yves
dc.contributor.advisorMacNaughton, Wallace K.
dc.contributor.authorWu, Theresa Faith
dc.date.accessioned2017-12-18T22:32:23Z
dc.date.available2017-12-18T22:32:23Z
dc.date.issued2006
dc.descriptionBibliography: p. 152-169en
dc.descriptionA few pages are in colour.en
dc.description.abstractLymphatics play a vital role in the maintenance of tissue homeostasis, and are especially important in the resolution of inflammation-associated edema. Whether this function is preserved under inflammatory conditions has to be demonstrated. The aim of this thesis was to (1) develop a protocol for investigating lymphatic vessel function during gastrointestinal inflammation (2) characterize the response of the lymphatics to gastrointestinal inflammation, and (3) investigate possible mechanisms of altered lymphatic vessel behaviour under these conditions. Specifically, the role of cyclooxygenases was investigated. Experiments were conducted both in vivo and in vitro using a guinea pig model of gastrointestinal inflammation. Results showed that lymphatic vessel behaviour was indeed altered during inflammation; the degree of alteration was found to correlate with the severity of inflammation, lymphatic contractile activity was partially abolished, vessels were distended, and the amplitude of lymphatic wall constrictions was altered. Flow rate and stroke volume were also significantly reduced. These functions were partially restored by the inhibition of cyclooxygenases.
dc.format.extentxiii, 176 leaves : ill. ; 30 cm.en
dc.identifier.citationWu, T. F. (2006). Lymphatic vessel function in a guinea pig model of intestinal inflammation, and the role of inflammatory mediators (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4804en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/4804
dc.identifier.urihttp://hdl.handle.net/1880/105805
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleLymphatic vessel function in a guinea pig model of intestinal inflammation, and the role of inflammatory mediators
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 2079 627942951
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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