Characteristics of Donor-Specific anti-HLA Antibodies (DSA) Impacting different Renal Allograft Outcomes

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atmire.migration.oldid3069
dc.contributor.advisorBerka, Noureddine
dc.contributor.advisorKhan, Faisal
dc.contributor.authorGhandorah, Salim
dc.date.accessioned2015-04-20T22:01:27Z
dc.date.available2015-06-22T07:00:43Z
dc.date.issued2015-04-20
dc.date.submitted2015en
dc.description.abstractAMR is the major complication of renal transplantation that significantly affects the allograft survival. Complement fixation of Donor specific anti-HLA antibodies is the hallmark of AMR. Different methods have been developed to detect harmful DSAs. However, not all DSAs have the same detrimental effect, as different antibody characteristics (timing, specificity, strength, and complement-fixing ability) might trigger distinct immune responses. Here, we assessed DSA characteristics in renal transplant patients. Thirty-nine patients with de novo DSA were analyzed for the DSA MFI values, C1q positivity and IgG subclasses. IgG1 was the predominant IgG subclass (49.4%), followed by IgG3 (24.7%), IgG2 (16%), and IgG4 (9.9%). Among DSA characteristics, DSA MFI and IgG1 subclass were strongly correlated with C1q positivity (p= 0.01 and p= 0.009, respectively). Further studies are needed to investigate the clinical relevance of high MFI DSA and IgG1 subclass in improving the utility of the C1q assay in predicting graft outcomes.en_US
dc.identifier.citationGhandorah, S. (2015). Characteristics of Donor-Specific anti-HLA Antibodies (DSA) Impacting different Renal Allograft Outcomes (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25256en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25256
dc.identifier.urihttp://hdl.handle.net/11023/2148
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectImmunology
dc.subject.classificationKidney Transplantationen_US
dc.subject.classificationantibodyen_US
dc.subject.classificationrejectionen_US
dc.titleCharacteristics of Donor-Specific anti-HLA Antibodies (DSA) Impacting different Renal Allograft Outcomes
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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