The Identification of Target Gene  to Increase Immunotherapy Response in Patients with Solid Tumors using Experimental and Computational Approaches

Nasr, Sahar

The Identification of Target Gene to Increase Immunotherapy Response in Patients with Solid Tumors using Experimental and Computational Approaches

dc.contributor.advisor	Wang, Edwin
dc.contributor.advisor	Mahoney, Douglas
dc.contributor.author	Nasr, Sahar
dc.contributor.committeemember	Bathe, Oliver
dc.contributor.committeemember	Bose, Pinaki
dc.date	2023-10
dc.date.accessioned	2023-07-17T16:46:36Z
dc.date.available	2023-07-17T16:46:36Z
dc.date.issued	2023-07
dc.description.abstract	Conventional cancer therapies have limitations which can lead to high recurrence rates and reduced quality of life. Immune checkpoint inhibitors (ICI) have been shown to have more durable responses and fewer side effects. This makes them an alternative treatment for solid tumors like bladder cancer and MSI-high colorectal carcinoma. However, many patients do not respond to ICI or develop resistance due to factors such as the absence of CD8+ T cells in the tumor microenvironment, dysfunctional CD8+ T cells, and impaired tumor-specific memory T cells generation. This study shows that inhibiting Sun1 enhances tumor-infiltrating lymphocyte infiltration, inhibits tumor growth in mice, and improves the response to anti-PD-1 treatment. Although the role of Sun1 in chromatin organization and gene expression regulation is not fully clear, its inhibition can upregulate the immune-related genes within the knockout cell lines. This approach suggests a potential strategy for enhancing ICI effectiveness in cancer treatment.
dc.identifier.citation	Nasr, S. (2023). The identification of target gene to increase immunotherapy response in patients with solid tumors using experimental and computational approaches (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.uri	https://hdl.handle.net/1880/116738
dc.identifier.uri	https://dx.doi.org/10.11575/PRISM/41580
dc.language.iso	en
dc.publisher.faculty	Graduate Studies
dc.publisher.institution	University of Calgary
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	Bioinformatics
dc.subject	Immunotherpy
dc.subject	Cancer
dc.subject	Genomics
dc.subject.classification	Bioinformatics
dc.subject.classification	Biology--Molecular
dc.subject.classification	Oncology
dc.title	The Identification of Target Gene to Increase Immunotherapy Response in Patients with Solid Tumors using Experimental and Computational Approaches
dc.type	master thesis
thesis.degree.discipline	Medicine – Biochemistry and Molecular Biology
thesis.degree.grantor	University of Calgary
thesis.degree.name	Master of Science (MSc)
ucalgary.thesis.accesssetbystudent	I require a thesis withhold – I need to delay the release of my thesis due to a patent application, and other reasons outlined in the link above. I have/will need to submit a thesis withhold application.