Reliability Architecture and Aging: Degeneration and Robustness in a Low Redundancy Neuronal Control System, VD1 and RPD2 Body Water Homeostasis in Lymnaea stagnalis

dc.contributor.advisorWildering, Willem Carel
dc.contributor.authorMcFadden, Eamon Sean Patrick
dc.contributor.committeememberBarclay, Robert
dc.contributor.committeememberSyme, Douglas
dc.date2024-05
dc.date.accessioned2024-01-30T19:34:45Z
dc.date.available2024-01-30T19:34:45Z
dc.date.issued2024-01-30
dc.description.abstractVD1 and RPD2 are two electrotonically coupled, peptidergic neurons that form an essential low redundancy neural control system in the central nervous system of the Great Pond Snail Lymnaea stagnalis. VD1 and RPD2 have been shown to exert a cardioregulatory role fundamental to proper osmoregulatory function. The performance of the electrical synapse between the two neurons has been shown to change dramatically with age. This change in performance between the neurons occurs concurrently with an increase in the mortality rate of the population. Additionally, ablation of one of the neurons exerting control over these functions has extreme consequences to the organism’s survival. This includes other measures of body water homeostasis thus demonstrating how dramatic the consequences of a lack of system redundancy can be. This thesis explores the intersection of reliability architecture and aging in a low redundancy neural control system. I will provide evidence for the following ideas: 1) The VD1/RPD2 system experiences age-associated declines in performance however, this decline is not uniform throughout the population. 2) Aging in VD1 and RPD2 result in a reduced capacity for acute adaptation to osmotic changes in the external environment. 3) Despite its low redundancy and the accumulation of age-related damage, VD1 and RPD2 prove robust over the lifespan and home-osmotic range of L. stagnalis.
dc.identifier.citationMcFadden, E. S. P. (2024). Reliability architecture and aging: degeneration and robustness in a low redundancy neuronal control system, VD1 and RPD2 body water homeostasis in Lymnaea stagnalis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/118143
dc.identifier.urihttps://doi.org/10.11575/PRISM/42987
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectLymnaea stagnalis
dc.subjectgastropod
dc.subjectVD2 and RPD2
dc.subjectaging
dc.subjectreliability theory
dc.subjectbody water
dc.subjecthomeostasis
dc.subjectosmoregulation
dc.subjectosmotic stimuli
dc.subjectelectrophysiology
dc.subjectelectrical synapse
dc.subjectgap junction
dc.subject.classificationAnimal Physiology
dc.subject.classificationEcology
dc.subject.classificationNeuroscience
dc.subject.classificationZoology
dc.titleReliability Architecture and Aging: Degeneration and Robustness in a Low Redundancy Neuronal Control System, VD1 and RPD2 Body Water Homeostasis in Lymnaea stagnalis
dc.typemaster thesis
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
ucalgary_2024_mcfadden_eamon.pdf
Size:
1.68 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.62 KB
Format:
Item-specific license agreed upon to submission
Description: