Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model

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dc.contributor.authorHerzog, Walter
dc.contributor.authorCollins, Kelsey H
dc.contributor.authorPaul, Heather A
dc.contributor.authorReimer, Raylene A
dc.contributor.authorSeerattan, Ruth A
dc.contributor.authorHart, David A
dc.date.accessioned2016-06-21T19:46:01Z
dc.date.available2016-06-21T19:46:01Z
dc.date.issued2016
dc.description.abstractWestern-type diets, high in fat and sugars, lead to obesity. Obesity in turn is associated with chronic inflammation, and thought to be a risk factor for the onset and increased rate of progression of metabolic osteoarthritis (OA) in joints. Emerging evidence suggests that intrinsic inflammatory mediators secreted by body fat, or adipose tissue, including cytokines, adipokines, and advanced glycation end products, may be sufficient to lead to onset and progression of OA. It appears that these obesity-associated, intrinsic inflammatory factors define a metabolic subtype of osteoarthritis. Characterizing the factors that comprise this unhealthy metabolic phenotype is critical to understanding the influence of obesity on OA. Furthermore, establishing the “indirect” role of the microbiota and the gut is required to fully understand the initiators and drivers of metabolic OA.en_US
dc.description.refereedYesen_US
dc.identifier.citationKH Collins, HA Paul, RA Reimer, RA Seerattan, DA Hart, W Herzog (2015) Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model. Osteoarthritis and Cartilage. 23(11):1989-1998. DOI: 10.1016/j.joca.2015.03.014en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/29061
dc.identifier.urihttp://hdl.handle.net/1880/51417
dc.language.isoenen_US
dc.publisher.departmentHuman Performance Laboratoryen_US
dc.publisher.facultyKinesiologyen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectobesityen_US
dc.subjectmetabolic osteoarthritisen_US
dc.subjectinflammationen_US
dc.subjecthigh-fat dietsen_US
dc.titleRelationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat modelen_US
dc.typejournal article
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