The nature of regulatory t cell interactions with dendritic cells

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dc.contributor.advisorShi, Yan
dc.contributor.authorMucsi, Ashley Dawn
dc.date.accessioned2017-12-18T22:35:30Z
dc.date.available2017-12-18T22:35:30Z
dc.date.issued2012
dc.descriptionBibliography: p. 93-103en
dc.descriptionSome pages are in colour.en
dc.descriptionIncludes copy of animal protocol approval. Original copy with original Partial Copyright Licence.en
dc.description.abstractThe immune system has developed several mechanisms responsible for discriminating against self and non-self antigens and preventing autoimmune responses from occurring within the body. Inactivation of auto-reactive lymphocytes and elimination of these cells prevents the generation of autoimmune responses ensuring that tolerance results in the periphery. A specialized subpopulation of CD4+ T cells, regulatory T cells (Tregs ), maintains peripheral self-tolerance through a diverse set of mechanisms. The mechanisms utilized by regulatory T cells are vast; however, the mechanisms by which Tregs modulate their suppressive function are not yet fully understood. Utilizing atomic force microscopy, we demonstrate that IL-2 stimulated Tregs interact intensely with dendritic cells (DC), which is dependent upon the LFA-1/ICAM-1 adhesion molecule. We propose that LF A-1 regulation differs between Tregs and CD4+ CD25- T cells, allowing Tregs to interact intensely with DCs abrogating any interaction with antigen­specific T cells. Our results illustrate how Tregs interact with DCs and its association with LF A-1 avidity regulation.
dc.format.extentxi, 103 leaves : ill. ; 30 cm.en
dc.identifier.citationMucsi, A. D. (2012). The nature of regulatory t cell interactions with dendritic cells (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4954en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/4954
dc.identifier.urihttp://hdl.handle.net/1880/105955
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleThe nature of regulatory t cell interactions with dendritic cells
dc.typemaster thesis
thesis.degree.disciplineMicrobiology, Immunology and Infectious Diseases
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 2114 627942984
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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