Examining Brain Structure after Pediatric Mild Traumatic Brain Injury

dc.contributor.advisorLebel, Catherine
dc.contributor.advisorYeates, Keith O.
dc.contributor.authorShukla, Ayushi
dc.contributor.committeememberHarris, Ashley
dc.contributor.committeememberBrooks, Brian
dc.date2023-02
dc.date.accessioned2022-11-30T15:41:00Z
dc.date.available2022-11-30T15:41:00Z
dc.date.issued2022-11-28
dc.description.abstractMild traumatic brain injuries (mTBIs) affect millions of children annually and present a huge burden to the public health care system. mTBIs often lead to emotional, cognitive, and physical difficulties, together known as post concussive symptoms (PCS), which usually resolve within 4 weeks of injury. In up to one third of all mTBI cases, PCS can be longer lasting and are referred to as persistent PCS (PPCS). In the pediatric population, since mTBI occurs when the brain is still developing, it can lead to altered developmental trajectories, and consequently affect children's cognitive functioning, symptomatology, and quality of life. This thesis aimed to use advanced neuroimaging techniques, [i.e., diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI), and voxel-based morphometry (VBM)] to study unexamined aspects of brain structure associated with mTBI, PPCS, and neurocognitive outcomes after mTBI. I used DTI and NODDI to examine white matter microstructure after mTBI at different time points after injury in comparison to orthopedic injury (OI) and used VBM to examine cerebellar gray matter volume and its association to neurocognitive outcomes of mTBI. The results revealed: 1) No post-acute differences in brain structure (white matter microstructure or gray matter) between children with mTBI or OI, 2) Age moderated differential trajectories of white matter change, 3- and 6-months post-injury in symptomatic children with mTBI compared to asymptomatic children with mTBI and an OI comparison group, 3) Higher gray matter volume in the motor regions of the cerebellum 3-months after injury in the mTBI compared to the OI group, 4) Disruptions in the association between reaction time and cerebellar volume in children with mTBI. This novel set of studies provides new knowledge about brain structure following pediatric mTBI and has important implications for improving our understanding of neurobiological correlates of pediatric mTBI.en_US
dc.identifier.citationShukla, A. (2022). Examining brain structure after pediatric mild traumatic brain Injury (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.urihttp://hdl.handle.net/1880/115559
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/40505
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subject.classificationEducation--Healthen_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationMental Healthen_US
dc.titleExamining Brain Structure after Pediatric Mild Traumatic Brain Injuryen_US
dc.typedoctoral thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameDoctor of Philosophy (PhD)en_US
ucalgary.item.requestcopytrueen_US
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