Effects of Interval Exercise on Commonly Studied Fluid Biomarkers for Sport-related Concussion in Serum and Plasma

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dc.contributor.advisorSmirl, Jonathan
dc.contributor.advisorEmery, Carolyn
dc.contributor.authorPenner, Linden
dc.contributor.committeememberDebert, Chantel
dc.contributor.committeememberWellington, Cheryl
dc.contributor.committeememberFraser, Douglas
dc.date2022-11
dc.date.accessioned2022-06-30T17:54:05Z
dc.date.available2022-06-30T17:54:05Z
dc.date.issued2022-06
dc.description.abstractHigh intensity interval exercise has been shown to increase blood levels of commonly studied fluid biomarkers for SRC. If true, the potential diagnostic or prognostic applications of these markers for SRC may be limited due to exercise being implicit in sport. This thesis examines the effects of interval exercise on serially collected plasma levels of t-tau, GFAP, NFL, and UCH-L1 in healthy young adults (7 females; 3 males), and differences in biomarker levels between plasma and serum matrices. The first study showed small and short-lived decreases in plasma NFL and GFAP immediately following interval exercise. The second study demonstrated differences between plasma and serum concentrations of t-tau, NFL, and GFAP. Together, these results suggest exercise should be considered prior to the clinical validation of these biomarkers for diagnosis or prognosis of SRC and highlights the need to harmonize analytical methodologies across research investigations aiming to develop objective measures of SRC.en_US
dc.identifier.citationPenner, L. (2022). Effects of interval exercise on commonly studied fluid biomarkers for sport-related concussion in serum and plasma (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/39861
dc.identifier.urihttp://hdl.handle.net/1880/114784
dc.language.isoengen_US
dc.publisher.facultyKinesiologyen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectsport-related concussionen_US
dc.subjectinterval exerciseen_US
dc.subjectblood biomarkersen_US
dc.subjecttauen_US
dc.subjectGFAPen_US
dc.subjectNFLen_US
dc.subjectUCH-L1en_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationPhysiologyen_US
dc.titleEffects of Interval Exercise on Commonly Studied Fluid Biomarkers for Sport-related Concussion in Serum and Plasmaen_US
dc.typemaster thesisen_US
thesis.degree.disciplineKinesiologyen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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